Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles

• Published in: Cell reports (Cambridge) Vol. 18; no. 11; pp. 2780 - 2794
• Main Authors: Gingras, Marie-Claude, Shih, Juliann, Hinoue, Toshinori, Hoadley, Katherine A., Gibb, Ewan A., Covington, Kyle R., Sadeghi, Sara, Pedamallu, Chandra Sekhar, Auman, J. Todd, Andersen, Jesper B., Bardeesy, Nabeel, Berrios, Mario, Bodenheimer, Tom, Boice, Lori, Bootwalla, Moiz S., Bowlby, Reanne, Bragazzi, Maria Consiglia, Cardinale, Vincenzo, Carlsen, Rebecca, Carpino, Guido, Chaiteerakij, Roongruedee, Chandan, Vishal C., Cherniack, Andrew D., Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cordes, Matthew G., Crain, Daniel, Curley, Erin, De Rose, Agostino Maria, Defreitas, Timothy, Demchok, John A., Ferguson, Martin L., Foo, Wai Chin, Franchitto, Antonio, Frazer, Scott, Fulton, Lucinda A., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Genovese, Giannicola, Giama, Nasra H., Hegde, Apurva M., Heiman, David I., Holbrook, Andrea, Holt, Robert A., Hoyle, Alan P., Jefferys, Stuart R., Jones, Steven J.M., Kasaian, Katayoon, Kwong, Lawrence N., Lai, Phillip H., Liu, Wenbin, Lolla, Laxmi, Lu, Yiling, Mardis, Elaine R., Matsushita, Marcus M., Mayo, Michael, McLellan, Michael D., Meier, Sam, Mounajjed, Taofic, Naresh, Rashi, Newton, Yulia, Noble, Michael S., Ojesina, Akinyemi I., Parker, Joel S., Patel, Tushar C., Pihl, Todd, Radenbaugh, Amie J., Ramirez, Nilsa C., Reznik, Ed, Robertson, A. Gordon, Saksena, Gordon, Schein, Jacqueline E., Schmidt, Heather K., Shelton, Troy, Shroff, Rachna, Simons, Janae V., Skelly, Tara, Stransky, Nicolas, Tan, Donghui, Thiessen, Nina, Veluvolu, Umadevi, Verhaak, Roel G.W., Wang, Zhining, Weinstein, John N., Wilson, Richard K., Wu, Chia-Chin, Yang, Liming, Zmuda, Erik, Stuart, Josh M., Sander, Chris, Laird, Peter W., Wheeler, David A., Roberts, Lewis R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.03.2017; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; ARID1A; Bile Duct Neoplasms - enzymology; Bile Duct Neoplasms - genetics; cholangiocarcinoma; Cholangiocarcinoma - enzymology; Cholangiocarcinoma - genetics; Chromatin - metabolism; DNA methylation; DNA Methylation - genetics; Female; Gene Expression Regulation, Neoplastic; Genomics - methods; Humans; IDH; integrative genomics; Isocitrate Dehydrogenase - genetics; Liver - pathology; Liver Neoplasms - genetics; Liver Neoplasms - pathology; lncRNAs; Male; Middle Aged; Mitochondria - metabolism; multi-omics; Mutation - genetics; Nuclear Proteins - genetics; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Promoter Regions, Genetic - genetics; RNA sequencing; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; TCGA; Transcription Factors - genetics; whole exome; RNA sequencing; lncRNAs; integrative genomics; whole exome; multi-omics; DNA methylation; IDH; ARID1A; cholangiocarcinoma; TCGA

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepati...