Rhesus macaque social functioning is paternally, but not maternally, inherited by sons: potential implications for autism

• Published in: Molecular autism Vol. 14; no. 1; pp. 25 - 10
• Main Authors: Garner, Joseph P., Talbot, Catherine F., Del Rosso, Laura A., McCowan, Brenda, Kanthaswamy, Sreetharan, Haig, David, Capitanio, John P., Parker, Karen J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.07.2023; BioMed Central; BMC
• Subjects: Analysis; Animals; Autism; Autism spectrum disorder; Autistic Disorder - genetics; Autistic traits; Behavior; Care and treatment; Diagnosis; Family; Female; Genetic aspects; Genetic susceptibility; Heritability; Humans; Macaca mulatta; Male; Monkeys & apes; Mothers; Nuclear Family; Parent of origin effect; Phenotype; Primate model; Rhesus macaque; Siblings; Social behavior in animals; Social Interaction; United States; Parent of origin effect; Autistic traits; Heritability; Social Responsiveness Scale; Rhesus macaque; Social functioning; Autism spectrum disorder; Primate model
• ISSN: 2040-2392; 2040-2392
• DOI: 10.1186/s13229-023-00556-3

Quantitative autistic traits are common, heritable, and continuously distributed across the general human population. Patterns of autistic traits within families suggest that more complex mechanisms than simple Mendelian inheritance-in particular, parent of origin effects-may be involved. The ideal...