Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells

• Published in: Cancer research (Chicago, Ill.) Vol. 65; no. 17; pp. 7691 - 7698
• Main Authors: POLETTE, Myriam, GILLES, Christine, NAWROCKI-RABY, Béatrice, LOHI, Jouko, HUNZIKER, Walter, FOIDART, Jean-Michel, BIREMBAUT, Philippe
• Format: Journal Article Web Resource
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.09.2005; American Association for Cancer Research, Inc. (AACR)
• Subjects: beta Catenin; Biological and medical sciences; Breast Neoplasms; Breast Neoplasms - enzymology; Breast Neoplasms - genetics; Cytoplasm; Cytoplasm - metabolism; Cytoskeletal Proteins; Cytoskeletal Proteins - genetics; DNA, Complementary; DNA, Complementary - genetics; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gynecology. Andrology. Obstetrics; Human health and pathology; Human health sciences; Humans; Life Sciences; Mammary gland diseases; Matrix Metalloproteinases, Membrane-Associated; Medical sciences; Membrane Proteins; Membrane Proteins - genetics; Membrane Proteins - metabolism; Metalloend; Metalloendopeptidases - biosynthesis; Metalloendopeptidases - genetics; Neoplasm Invasiveness; Oncologie; Oncology; Phosphoproteins - genetics; Phosphoproteins - metabolism; Promoter Regions, Genetic; Pulmonology and respiratory tract; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; RNA, Small Interfering - genetics; Sciences de la santé humaine; Trans-Activators - genetics; Transcriptional Activation; Transfection; Tumors; Zonula Occludens-1 Protein; Human; Enzyme; Cell junction; Metalloendopeptidases; Breast cancer; Malignant tumor; Gene expression; Occludin; Mammary gland diseases; Peptidases; Regulation(control); Hydrolases; Tight junction; Tumor cell; Interstitial collagenase

The acquisition of a migratory/invasive phenotype by tumor cells is characterized by the loss of cell-cell adhesion contacts and the expression of degradative properties. In this study, we examined the effect of the disorganization of occludin/zonula occludens (ZO)-1 tight junction (TJ) complexes on...