Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases

[Display omitted] We synthesized 11 kinds of prodrug with an esterified carboxylic acid moiety of atorvastatin in moderate to high yields. We discovered that they underwent metabolic activation specifically by the human carboxylesterase 1 (CES1) isozyme. The results suggested that these ester compou...

Full description

Saved in:
Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 26; no. 3; pp. 921 - 923
Main Authors Mizoi, Kenta, Takahashi, Masato, Haba, Masami, Hosokawa, Masakiyo
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.02.2016
Elsevier
Subjects
Online AccessGet full text

Cover

Loading…