A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence

• Published in: Cell reports (Cambridge) Vol. 23; no. 2; pp. 637 - 651
• Main Authors: de Souza, Camila Ferreira, Sabedot, Thais S., Malta, Tathiane M., Stetson, Lindsay, Morozova, Olena, Sokolov, Artem, Laird, Peter W., Wiznerowicz, Maciej, Iavarone, Antonio, Snyder, James, deCarvalho, Ana, Sanborn, Zachary, McDonald, Kerrie L., Friedman, William A., Tirapelli, Daniela, Poisson, Laila, Mikkelsen, Tom, Carlotti, Carlos G., Kalkanis, Steven, Zenklusen, Jean, Salama, Sofie R., Barnholtz-Sloan, Jill S., Noushmehr, Houtan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.04.2018; Elsevier
• Subjects: Adult; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Brain Neoplasms - genetics; Brain Neoplasms - mortality; Brain Neoplasms - pathology; Brain Neoplasms - therapy; CpG Islands; DNA Methylation; Female; G-CIMP-high; G-CIMP-low; Genomic Instability; Glioma - genetics; Glioma - mortality; Glioma - pathology; Glioma - therapy; Humans; IDH mutation; intra-subtype heterogeneity; Isocitrate Dehydrogenase - genetics; Kaplan-Meier Estimate; longitudinal gliomas; Longitudinal Studies; Male; malignant transformation and recurrence; Middle Aged; Mutation; Neoplasm Grading; Neoplasm Recurrence, Local - genetics; Neoplastic Stem Cells - cytology; Neoplastic Stem Cells - metabolism; Phenotype; predictive biomarkers; Prognosis; stem cell-like glioblastoma; intra-subtype heterogeneity; predictive biomarkers; G-CIMP-high; malignant transformation and recurrence; longitudinal gliomas; DNA methylation; G-CIMP-low; IDH mutation; stem cell-like glioblastoma

Glioma diagnosis is based on histomorphology and grading; however, such classification does not have predictive clinical outcome after glioblastomas have developed. To date, no bona fide biomarkers that significantly translate into a survival benefit to glioblastoma patients have been identified. We...