Epigenetic assimilation in the aging human brain

• Published in: Genome Biology Vol. 17; no. 1; p. 76
• Main Authors: Oh, Gabriel, Ebrahimi, Sasha, Wang, Sun-Chong, Cortese, Rene, Kaminsky, Zachary A., Gottesman, Irving I., Burke, James R., Plassman, Brenda L., Petronis, Art
• Format: Journal Article
• Language: English
• Published: England BioMed Central 28.04.2016
• Subjects: Age; Aged; Aged, 80 and over; Aging; Alzheimer disease; Alzheimer Disease - genetics; Alzheimer's disease; Assimilation; Bioinformatics; Brain; cell dedifferentiation; cell senescence; Cerebellum; Cerebral cortex; Consortia; Datasets; Deoxyribonucleic acid; DNA; DNA Methylation; Epigenesis, Genetic; Epigenetics; Female; Frontal Lobe - growth & development; Frontal Lobe - metabolism; Frontal Lobe - physiology; Genomes; Humans; Male; Middle Aged; Molecular modelling; Neurodegenerative diseases; risk factors; Stem cells; Studies; tissues; Transcription; transcription (genetics); transcriptomics; Twins; Alzheimer’s disease; Dedifferentiation; Transcriptome; Aging; DNA methylation; Epigenetics; Genomic organization; Epigenetic drift

Epigenetic drift progressively increases variation in DNA modification profiles of aging cells, but the finale of such divergence remains elusive. In this study, we explored the dynamics of DNA modification and transcription in the later stages of human life. We find that brain tissues of older indi...