Spatial regulation of coordinated excitatory and inhibitory synaptic plasticity at dendritic synapses

• Published in: Cell reports (Cambridge) Vol. 38; no. 6; p. 110347
• Main Authors: Ravasenga, Tiziana, Ruben, Massimo, Regio, Vincenzo, Polenghi, Alice, Petrini, Enrica Maria, Barberis, Andrea
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.02.2022; Cell Press; Elsevier
• Subjects: Animals; CA1 Region, Hippocampal - physiology; calcium imaging; dendrites; Dendrites - physiology; GABA uncaging; GABAergic synaptic plasticity; gephyrin; glutamate uncaging; glutamatergic spines; glutamatergic synaptic plasticity; heterosynaptic plasticity; Long-Term Potentiation - physiology; Mice; Neuronal Plasticity - physiology; Neurons - physiology; receptor lateral diffusion; Synapses - physiology; GABA uncaging; glutamatergic spines; heterosynaptic plasticity; glutamatergic synaptic plasticity; receptor lateral diffusion; dendrites; glutamate uncaging; gephyrin; calcium imaging; GABAergic synaptic plasticity

The induction of synaptic plasticity at an individual dendritic glutamatergic spine can affect neighboring spines. This local modulation generates dendritic plasticity microdomains believed to expand the neuronal computational capacity. Here, we investigate whether local modulation of plasticity can...