Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet

• Published in: The American journal of clinical nutrition Vol. 89; no. 1; pp. 248 - 256
• Main Authors: Mena, Mari-Pau, Sacanella, Emilio, Vazquez-Agell, Mónica, Morales, Mercedes, Fitó, Montserrat, Escoda, Rosa, Serrano-Martínez, Manuel, Salas-Salvadó, Jordi, Benages, Neus, Casas, Rosa, Lamuela-Raventós, Rosa M, Masanes, Ferran, Ros, Emilio, Estruch, Ramon
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.01.2009; American Society for Clinical Nutrition; American Society for Nutrition; American Society for Clinical Nutrition, Inc
• Subjects: administration & dosage; Aged; Aged, 80 and over; anti-inflammatory activity; atherogenesis; Biological and medical sciences; biomarkers; Biomarkers - blood; biosynthesis; blood; blood chemistry; C-reactive protein; C-Reactive Protein - metabolism; Cardiovascular disease; Cardiovascular Diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - immunology; Cardiovascular Diseases - prevention & control; Cells; Cytokines; Cytokines - biosynthesis; Cytokines - blood; Diet; Diet, Fat-Restricted; Diet, Mediterranean; elderly; epidemiology; Feeding. Feeding behavior; Female; food choices; food intake; Fundamental and applied biological sciences. Psychology; Humans; Immune system; Immunity, Cellular; immunology; Inflammation; Inflammation - blood; Inflammation - immunology; Intercellular Adhesion Molecule-1; Intercellular Adhesion Molecule-1 - blood; interleukin-6; leukocytes; Leukocytes, Mononuclear; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - physiology; low fat diet; Male; mechanism of action; Mediterranean diet; men; metabolism; Middle Aged; Molecular biology; Nutrition; Nuts; Olea; Olive Oil; physiology; Plant Oils; Plant Oils - administration & dosage; prevention & control; Risk Factors; risk reduction; temporal variation; Vascular Cell Adhesion Molecule-1; Vascular Cell Adhesion Molecule-1 - blood; vascular cellular adhesion molecule-1; Vertebrates: anatomy and physiology, studies on body, several organs or systems; women; Human; Mediterranean diet; Antiinflammatory agent; Activation; A-Cell; Inhibition; Molecular biology

Adherence to the Mediterranean diet (Med-Diet) is associated with a reduced risk of cardiovascular disease (CVD). However, the molecular mechanisms involved are not fully understood. The objective was to compare the effects of 2 Med-Diets with those of a low-fat diet on immune cell activation and so...