Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

• Published in: Cell reports (Cambridge) Vol. 28; no. 12; pp. 3249 - 3262.e5
• Main Authors: Hinks, Timothy S.C., Marchi, Emanuele, Jabeen, Maisha, Olshansky, Moshe, Kurioka, Ayako, Pediongco, Troi J., Meehan, Bronwyn S., Kostenko, Lyudmila, Turner, Stephen J., Corbett, Alexandra J., Chen, Zhenjun, Klenerman, Paul, McCluskey, James
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.09.2019; Cell Press; Elsevier
• Subjects: activation; Animals; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - immunology; human; Humans; lung; Lymphocyte Activation; MHC-related protein 1; Mice; mouse; Mucosal-Associated Invariant T Cells - cytology; Mucosal-Associated Invariant T Cells - immunology; mucosal-associated invariant T cell; Natural Killer T-Cells - cytology; Natural Killer T-Cells - immunology; riboflavin; T cell; tissue repair; transcriptome; Transcriptome - immunology; lung; mouse; mucosal-associated invariant T cell; T cell; transcriptome; activation; human; MHC-related protein 1; riboflavin; tissue repair

Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine lungs, we define the basic transcriptome of an activat...