Gene expression analysis in predicting the effectiveness of insect venom immunotherapy

• Published in: Journal of allergy and clinical immunology Vol. 125; no. 5; pp. 1092 - 1097
• Main Authors: Niedoszytko, Marek, Bruinenberg, Marcel, de Monchy, Jan, Wijmenga, Cisca, Platteel, Mathieu, Jassem, Ewa, Oude Elberink, Joanne N.G.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.05.2010; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Allergies; Allergy and Immunology; Animals; Arthropod Venoms - administration & dosage; Arthropod Venoms - immunology; Bee Venoms - administration & dosage; Bee Venoms - immunology; Bees - immunology; Biological and medical sciences; Desensitization, Immunologic; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene expression; Gene Expression Profiling - methods; Humans; Hypersensitivity, Immediate - etiology; Hypersensitivity, Immediate - immunology; Hypersensitivity, Immediate - therapy; Immunopathology; Immunotherapy; Immunotherapy - methods; Insect Bites and Stings - immunology; Insect venom allergy; Male; Medical sciences; microarray assessment; Middle Aged; prediction of treatment efficacy; Proteins; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Treatment Outcome; Venom; venom immunotherapy; Wasp Venoms - administration & dosage; Wasp Venoms - immunology; Wasps - immunology; VIT; Insect venom allergy; TWIST2; microarray assessment; SNX33; MAPK; CLDN1; PRLR; STAT; IVA; venom immunotherapy; gene expression; prediction of treatment efficacy; SLC16A4; Claudin 1; Signal transducer and activator of transcription; sh3 and px domain containing 3; Mitogen-activated protein kinase; Solute carrier family 16; Transcription factor twist homolog 2; Prolactin receptor; Allergy; Immunopathology; Treatment efficiency; Insecta; Prediction; Gene expression; Immunology; Treatment; Arthropoda; Immunotherapy; Venom; Invertebrata; Predictive factor

Venom immunotherapy (VIT) enables longtime prevention of insect venom allergy in the majority of patients. However, in some, the risk of a resystemic reaction increases after completion of treatment. No reliable factors predicting individual lack of efficacy of VIT are currently available. To determ...