Amelioration effects of the soybean lecithin-gallic acid complex on iron-overload-induced oxidative stress and liver damage in C57BL/6J mice

• Published in: Pharmaceutical biology Vol. 61; no. 1; pp. 37 - 49
• Main Authors: Wu, Caihong, Zhang, Wenxin, Yan, Feifei, Dai, Wenwen, Fang, Fang, Gao, Yanli, Cui, Weiwei
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 31.12.2023; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: absorbance; Alanine transaminase; Animals; antioxidant activity; Antioxidants; Antioxidants - therapeutic use; Aspartate transaminase; Bioavailability; Biological Sciences; blood serum; Cholesterol; Deferoxamine; Deferoxamine - metabolism; Deferoxamine - pharmacology; Deferoxamine - therapeutic use; Drug delivery; drugs; excessive iron; Ferritin; Free radicals; Gallic acid; Gallic Acid - pharmacology; gamma-glutamyltransferase; Glutathione; Glycine max; hepatic damage; histopathology; Iron; Iron - metabolism; Iron Overload - drug therapy; Iron Overload - metabolism; Iron Overload - pathology; Lecithin; lecithins; Lecithins - metabolism; Lecithins - pharmacology; Lecithins - therapeutic use; Lipid Peroxidation; Liver; Liver Diseases - drug therapy; malondialdehyde; medicine; Mice; Mice, Inbred C57BL; Oxidative Stress; Phenolic acid; Photometry; soybeans; superoxide dismutase; transferrin receptors; triacylglycerols; excessive iron; hepatic damage; Phenolic acid; antioxidant activity

Gallic acid (GA) and lecithin showed important roles in antioxidant and drug delivery, respectively. A complex synthesized from GA and soybean lecithin (SL-GAC), significantly improved bioavailability of GA and pharmacological activities. However, the antioxidant activity of SL-GAC and its effect on...