Interleukin-6 Facilitates Lipopolysaccharide-Induced Disruption in Working Memory and Expression of Other Proinflammatory Cytokines in Hippocampal Neuronal Cell Layers

• Published in: The Journal of neuroscience Vol. 26; no. 42; pp. 10709 - 10716
• Main Authors: Sparkman, Nathan L, Buchanan, Jessica B, Heyen, Jonathan R. R, Chen, Jing, Beverly, James L, Johnson, Rodney W
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 18.10.2006; Society for Neuroscience
• Subjects: Animals; Cytokines - biosynthesis; Cytokines - genetics; Gene Expression Regulation - immunology; Hippocampus - metabolism; Inflammation Mediators - metabolism; Inflammation Mediators - physiology; Interleukin-6 - genetics; Interleukin-6 - physiology; Lipopolysaccharides - toxicity; Male; Memory - physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons - immunology; Neurons - metabolism

Proinflammatory cytokines inhibit learning and memory but the significance of interleukin-6 (IL-6) in acute cognitive deficits induced by the peripheral innate immune system is not known. To examine the functional role of IL-6 in hippocampus-mediated cognitive impairments associated with peripheral...