Systematic elucidation of the mechanism of geraniol via network pharmacology
Geraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of action has not yet been carried out. In this study, the druggability of geraniol was assessed via Traditional Chinese Medicine Systems Pharmacology Data...
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Published in | Drug design, development and therapy Vol. 13; pp. 1069 - 1075 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Dove Medical Press Limited
01.01.2019
Taylor & Francis Ltd Dove Medical Press |
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Abstract | Geraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of action has not yet been carried out.
In this study, the druggability of geraniol was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential targets of geraniol were identified using the Comparative Toxicogenomics Database (CTD). Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view.
Our findings showed that geraniol has superb druggability with 38 putative identified target genes. GO, KEGG, and network analyses revealed that these targets were associated with cancer, inflammatory immunoreactions, and other physiological processes.
Geraniol is predicted to target multiple proteins and pathways that shape a network which can exert systematic pharmacological effects. |
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AbstractList | BACKGROUNDGeraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of action has not yet been carried out. METHODSIn this study, the druggability of geraniol was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential targets of geraniol were identified using the Comparative Toxicogenomics Database (CTD). Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view. RESULTSOur findings showed that geraniol has superb druggability with 38 putative identified target genes. GO, KEGG, and network analyses revealed that these targets were associated with cancer, inflammatory immunoreactions, and other physiological processes. CONCLUSIONGeraniol is predicted to target multiple proteins and pathways that shape a network which can exert systematic pharmacological effects. Geraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of action has not yet been carried out. In this study, the druggability of geraniol was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential targets of geraniol were identified using the Comparative Toxicogenomics Database (CTD). Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view. Our findings showed that geraniol has superb druggability with 38 putative identified target genes. GO, KEGG, and network analyses revealed that these targets were associated with cancer, inflammatory immunoreactions, and other physiological processes. Geraniol is predicted to target multiple proteins and pathways that shape a network which can exert systematic pharmacological effects. Yun-Fei Zhang,* Yue Huang,* Yi-Hua Ni, Zheng-Min Xu Department of Otolaryngology-Head and Neck Surgery, Children's Hospital of Fudan University, Shanghai, People's Republic of China *These authors contributed equally to this work Background: Geraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of action has not yet been carried out. Methods: In this study, the druggability of geraniol was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential targets of geraniol were identified using the Comparative Toxicogenomics Database (CTD). Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view. Results: Our findings showed that geraniol has superb druggability with 38 putative identified target genes. GO, KEGG, and network analyses revealed that these targets were associated with cancer, inflammatory immunoreactions, and other physiological processes. Conclusion: Geraniol is predicted to target multiple proteins and pathways that shape a network which can exert systematic pharmacological effects. Keywords: geraniol, druggability, target prediction, enrichment analysis, network pharmacology Background: Geraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of action has not yet been carried out. Methods: In this study, the druggability of geraniol was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential targets of geraniol were identified using the Comparative Toxicogenomics Database (CTD). Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view. Results: Our findings showed that geraniol has superb druggability with 38 putative identified target genes. GO, KEGG, and network analyses revealed that these targets were associated with cancer, inflammatory immunoreactions, and other physiological processes. Conclusion: Geraniol is predicted to target multiple proteins and pathways that shape a network which can exert systematic pharmacological effects. Background: Geraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of action has not yet been carried out. Methods: In this study, the druggability of geraniol was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential targets of geraniol were identified using the Comparative Toxicogenomics Database (CTD). Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view. Results: Our findings showed that geraniol has superb druggability with 38 putative identified target genes. GO, KEGG, and network analyses revealed that these targets were associated with cancer, inflammatory immunoreactions, and other physiological processes. Conclusion: Geraniol is predicted to target multiple proteins and pathways that shape a network which can exert systematic pharmacological effects. Keywords: geraniol, druggability, target prediction, enrichment analysis, network pharmacology |
Audience | Academic |
Author | Xu, Zheng-Min Huang, Yue Zhang, Yun-Fei Ni, Yi-Hua |
AuthorAffiliation | Department of Otolaryngology-Head and Neck Surgery, Children’s Hospital of Fudan University, Shanghai, People’s Republic of China, xuzhengminsh@126.com |
AuthorAffiliation_xml | – name: Department of Otolaryngology-Head and Neck Surgery, Children’s Hospital of Fudan University, Shanghai, People’s Republic of China, xuzhengminsh@126.com |
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Keywords | target prediction druggability geraniol network pharmacology enrichment analysis |
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Snippet | Geraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of action has... Background: Geraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of... BACKGROUNDGeraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of... Yun-Fei Zhang,* Yue Huang,* Yi-Hua Ni, Zheng-Min Xu Department of Otolaryngology-Head and Neck Surgery, Children's Hospital of Fudan University, Shanghai,... |
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SubjectTerms | Acids Acyclic Monoterpenes Alcohols Asian medicine Bioavailability Chemical plants Chinese medicine Comparative analysis Databases, Pharmaceutical druggability Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Encyclopedias enrichment analysis Essential oils Genes Genomes Genomics Geraniol Herbal medicine Humans Identification Inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - immunology Investigations Medicine, Chinese Traditional Metabolism Molecular Structure Neoplasms - drug therapy Neoplasms - genetics network pharmacology Ontology Original Research Permeability Pharmacology Physiological aspects Proteins Proteomics target prediction Target recognition Terpenes - chemistry Terpenes - pharmacology Traditional Chinese medicine |
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Title | Systematic elucidation of the mechanism of geraniol via network pharmacology |
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