Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy

• Published in: Nature biotechnology Vol. 23; no. 11; pp. 1407 - 1413
• Main Authors: Bulte, Jeff W M, Figdor, Carl G, de Vries, I Jolanda M, Lesterhuis, W Joost, Barentsz, Jelle O, Verdijk, Pauline, van Krieken, J Han, Boerman, Otto C, Oyen, Wim J G, Bonenkamp, Johannes J, Boezeman, Jan B, Adema, Gosse J, Scheenen, Tom W J, Punt, Cornelis J A, Heerschap, Arend
• Format: Journal Article
• Language: English
• Published: New York, NY Nature 01.11.2005; Nature Publishing Group
• Subjects: Biological and medical sciences; Biotechnology; Cell Movement; Cell Separation; Cell Transplantation - methods; Dendritic Cells - transplantation; Ferric Compounds - chemistry; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Humans; Immune system; Immunohistochemistry; Immunotherapy - methods; Indium Radioisotopes - therapeutic use; Iron oxides; Lymph nodes; Lymph Nodes - pathology; Lymphatic Metastasis; Magnetic Resonance Imaging - methods; Melanoma; Melanoma - therapy; Models, Statistical; Monocytes - metabolism; Phenotype; Radionuclide Imaging - methods; Human; Dendritic cell; Cell therapy; Nuclear magnetic resonance imaging; Monitoring; Melanoma

The success of cellular therapies will depend in part on accurate delivery of cells to target organs. In dendritic cell therapy, in particular, delivery and subsequent migration of cells to regional lymph nodes is essential for effective stimulation of the immune system. We show here that in vivo ma...