Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

• Published in: Cell reports (Cambridge) Vol. 23; no. 4; pp. 1099 - 1111
• Main Authors: Krishnan, Smitha, Ding, Yufang, Saedi, Nima, Choi, Maria, Sridharan, Gautham V., Sherr, David H., Yarmush, Martin L., Alaniz, Robert C., Jayaraman, Arul, Lee, Kyongbum
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.04.2018; Elsevier
• Subjects: Animals; aryl hydrocarbon receptor; Cytokines - immunology; Cytokines - metabolism; Dietary Fats - pharmacology; Fatty Acid Synthase, Type I - immunology; Fatty Acid Synthase, Type I - metabolism; Gastrointestinal Microbiome - immunology; gut microbiota; Hep G2 Cells; Hepatocytes - immunology; Hepatocytes - metabolism; Hepatocytes - pathology; Humans; indole-3-acetate; Indoleacetic Acids - immunology; Indoleacetic Acids - metabolism; Inflammation; Macrophages - immunology; Macrophages - metabolism; Male; metabolomics; Mice; nonalcoholic fatty liver disease; RAW 264.7 Cells; Receptors, Aryl Hydrocarbon - immunology; Receptors, Aryl Hydrocarbon - metabolism; Sterol Regulatory Element Binding Protein 1 - immunology; Sterol Regulatory Element Binding Protein 1 - metabolism; Tryptamines - immunology; Tryptamines - metabolism; Tryptophan - immunology; Tryptophan - metabolism; nonalcoholic fatty liver disease; metabolomics; inflammation; gut microbiota; indole-3-acetate; aryl hydrocarbon receptor

The gut microbiota plays a significant role in the progression of fatty liver disease; however, the mediators and their mechanisms remain to be elucidated. Comparing metabolite profile differences between germ-free and conventionally raised mice against differences between mice fed a low- and high-f...