Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages - Krishnan, Smitha; Ding, Yufang; Saedi, Nima; Choi, Maria; Sridharan, Gautham V.; Sherr, David H.; Yarmush, Martin L.; Alaniz, Robert C.; Jayaraman, Arul; Lee, Kyongbum (Cell reports (Cambridge), 2018)
Keywords: Animals; aryl hydrocarbon receptor; Cytokines - immunology; Cytokines - metabolism; Dietary Fats - pharmacology; Fatty Acid Synthase, Type I - immunology; Fatty Acid Synthase, Type I - metabolism; Gastrointestinal Microbiome - immunology; gut microbiota; Hep G2 Cells; Hepatocytes - immunology; Hepatocytes - metabolism; Hepatocytes - pathology; Humans; indole-3-acetate; Indoleacetic Acids - immunology; Indoleacetic Acids - metabolism; Inflammation; Macrophages - immunology; Macrophages - metabolism; Male; metabolomics; Mice; nonalcoholic fatty liver disease; RAW 264.7 Cells; Receptors, Aryl Hydrocarbon - immunology; Receptors, Aryl Hydrocarbon - metabolism; Sterol Regulatory Element Binding Protein 1 - immunology; Sterol Regulatory Element Binding Protein 1 - metabolism; Tryptamines - immunology; Tryptamines - metabolism; Tryptophan - immunology; Tryptophan - metabolism; nonalcoholic fatty liver disease; metabolomics; inflammation; gut microbiota; indole-3-acetate; aryl hydrocarbon receptor