Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers

• Published in: Pharmaceutical biology Vol. 55; no. 1; pp. 1041 - 1046
• Main Authors: Chiu, Hui-Fang, Fu, Hui-Yu, Lu, Yan-Ying, Han, Yi-Chun, Shen, You-Cheng, Venkatakrishnan, Kamesh, Golovinskaia, Oksana, Wang, Chin-Kun
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2017; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Adult; Aging; alanine transaminase; Antifungal agents; antioxidant activity; Antioxidants; Antioxidants - pharmacology; aspartate transaminase; Cross-Over Studies; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - analysis; dinner; Double-Blind Method; Double-blind studies; Enzymes; Fatty liver; Female; females; Fungi; Ganoderma lucidum; Glutathione; Guanosine; Healthy Volunteers; hepatic markers; Hepatitis; Humans; Hyperglycemia; hypertension; Liver - drug effects; lunch; Male; males; medicinal fungi; Middle Aged; Oriental traditional medicine; Oxidative stress; Oxidative Stress - drug effects; placebos; Polyporaceae; Polysaccharides; Protective Agents - pharmacology; Proteoglycans - pharmacology; Reactive Oxygen Species - metabolism; Reishi - chemistry; Thiobarbituric acid; Thiols; Traditional Chinese medicine; Transaminase; Triterpenes - pharmacology; Triterpenoids; ultrasonic examination; ultrasonics; hepatic markers; Oxidative stress; fatty liver; ultrasonic examination

Context: Ganoderma lucidum (Leyss: Fr) Karst. (Polyporaceae) is an oriental medicinal fungus, commonly used in traditional Chinese medicine (TCM) for treating various condition or diseases such as hypertension, hyperglycaemia, hepatitis and cancer. Objective: The current study examines whether trite...