Evolutionary Conservation and Diversification of Rh Family Genes and Proteins

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 43; pp. 15512 - 15517
• Main Authors: Huang, Cheng-Han, Jianbin Peng
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 25.10.2005; National Acad Sciences
• Subjects: Amino Acid Sequence; Amino acids; Ammonia; Ammonia - metabolism; Base Sequence; Biological Evolution; Biological Sciences; Carbon dioxide; Carbon Dioxide - metabolism; Cation Transport Proteins - analysis; Cell membranes; Codons; Datasets; Divergent evolution; E coli; Escherichia coli; Evolution; Evolutionary biology; Fish; Gene expression; Humans; Molecular Sequence Data; Multigene Family; Negative selection; Phylogeny; Proteins; Rh-Hr Blood-Group System - analysis; Rh-Hr Blood-Group System - chemistry; Rh-Hr Blood-Group System - genetics; Vertebrates

Rhesus (Rh) proteins were first identified in human erythroid cells and recently in other tissues. Like ammonia transporter (Amt) proteins, their only homologues, Rh proteins have the 12 transmembrane-spanning segments characteristic of transporters. Many think Rh and Amt proteins transport the same...