Economical value of vaccines for the developing countries--the case of Instituto Butantan, a public institution in Brazil
The companies are understandably reluctant to create competitors with knowledge and capabilities in the most up-to-date production methods and most advanced vaccines. [...]the developing country partner may obtain out-of-date technology for older vaccines. Besides this, a federal regulatory agency...
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Published in | PLoS neglected tropical diseases Vol. 5; no. 11; p. e1300 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
01.11.2011
Public Library of Science (PLoS) |
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Abstract |
The companies are understandably reluctant to create competitors with knowledge and capabilities in the most up-to-date production methods and most advanced vaccines. [...]the developing country partner may obtain out-of-date technology for older vaccines. Besides this, a federal regulatory agency (ANVISA) was created that certifies the production laboratories and promotes a move to full compliance with WHO GMP guidance, a process that is not instantaneous but depends on investments that the MH began to make available starting in 1985. [...]the country should ensure the capability to undertake rigorous epidemiological studies to guide and evaluate the delivery of vaccination services. |
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AbstractList |
The companies are understandably reluctant to create competitors with knowledge and capabilities in the most up-to-date production methods and most advanced vaccines. [...]the developing country partner may obtain out-of-date technology for older vaccines. Besides this, a federal regulatory agency (ANVISA) was created that certifies the production laboratories and promotes a move to full compliance with WHO GMP guidance, a process that is not instantaneous but depends on investments that the MH began to make available starting in 1985. [...]the country should ensure the capability to undertake rigorous epidemiological studies to guide and evaluate the delivery of vaccination services. |
Audience | Academic |
Author | Raw, Isaias Kubrusly, Flavia Saldanha Tanizaki, Martha Massako Martins, Elizabeth Angélica Leme Dias, Waldely de Oliveira Ho, Paulo Lee Miyaji, Eliane Namie Oliveira, Maria Leonor Sarno |
AuthorAffiliation | Yale School of Public Health, United States of America 1 Instituto Butantan, São Paulo, SP, Brazil 2 Fundação Butantan, São Paulo, SP, Brazil |
AuthorAffiliation_xml | – name: 2 Fundação Butantan, São Paulo, SP, Brazil – name: 1 Instituto Butantan, São Paulo, SP, Brazil – name: Yale School of Public Health, United States of America |
Author_xml | – sequence: 1 givenname: Paulo Lee surname: Ho fullname: Ho, Paulo Lee organization: Instituto Butantan, São Paulo, SP, Brazil – sequence: 2 givenname: Eliane Namie surname: Miyaji fullname: Miyaji, Eliane Namie – sequence: 3 givenname: Maria Leonor Sarno surname: Oliveira fullname: Oliveira, Maria Leonor Sarno – sequence: 4 givenname: Waldely de Oliveira surname: Dias fullname: Dias, Waldely de Oliveira – sequence: 5 givenname: Flavia Saldanha surname: Kubrusly fullname: Kubrusly, Flavia Saldanha – sequence: 6 givenname: Martha Massako surname: Tanizaki fullname: Tanizaki, Martha Massako – sequence: 7 givenname: Elizabeth Angélica Leme surname: Martins fullname: Martins, Elizabeth Angélica Leme – sequence: 8 givenname: Isaias surname: Raw fullname: Raw, Isaias |
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CitedBy_id | crossref_primary_10_1016_j_vaccine_2014_07_069 crossref_primary_10_1038_s41598_022_11851_z crossref_primary_10_4161_hv_23163 crossref_primary_10_1371_journal_pone_0286224 crossref_primary_10_1016_j_provac_2015_05_001 crossref_primary_10_1016_j_tmaid_2022_102441 crossref_primary_10_1016_j_toxicon_2012_02_008 crossref_primary_10_1128_CVI_00134_14 crossref_primary_10_1016_j_vaccine_2017_04_087 crossref_primary_10_1371_journal_pntd_0002862 |
Cites_doi | 10.1016/j.vaccine.2009.04.047 10.1371/journal.pone.0010863 10.1016/j.vaccine.2010.01.044 10.1016/j.vaccine.2009.06.004 10.1016/j.vaccine.2011.04.127 10.1136/jech.2008.085712 10.1586/14760584.4.2.173 10.1128/CVI.00339-08 10.1097/INF.0b013e3181c15471 10.1016/j.vaccine.2009.12.026 10.1016/j.vaccine.2007.11.048 |
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Copyright | COPYRIGHT 2011 Public Library of Science Ho et al. 2011 2011 Ho et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Ho PL, Miyaji EN, Oliveira MLS, Dias WdO, Kubrusly FS, et al. (2011) Economical Value of Vaccines for the Developing Countries--The Case of Instituto Butantan, a Public Institution in Brazil. PLoS Negl Trop Dis 5(11): e1300. doi:10.1371/journal.pntd.0001300 |
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References | 21684420 - Vaccine. 2011 Jul 1;29 Suppl 1:A12-5 15889991 - Expert Rev Vaccines. 2005 Apr;4(2):173-84 20466706 - J Epidemiol Community Health. 2010 Jul;64(7):563-4 18155811 - Vaccine. 2008 Jan 30;26(5):647-52 19393709 - Vaccine. 2009 Jun 24;27(31):4219-24 19545935 - Vaccine. 2009 Aug 21;27 Suppl 3:C22-4 19935447 - Pediatr Infect Dis J. 2010 Apr;29(4):289-93 20523738 - PLoS One. 2010;5(5):e10863 20123051 - Vaccine. 2010 Mar 16;28(13):2505-9 19261771 - Clin Vaccine Immunol. 2009 Apr;16(4):544-50 20044050 - Vaccine. 2010 Feb 25;28(9):2130-6 JA Bettinger (ref6) 2010; 28 K Mulholland (ref11) 2010; 64 MS Brasil (ref12) 2009 W Quintilio (ref5) 2009; 27 C Miyaki (ref1) 2011; 29 EF Carniel (ref10) 2008; 26 C Miyaki (ref4) 2010; 28 M Watanabe (ref2) 2005; 4 TQ Zorzeto (ref3) 2009; 16 R Dagan (ref7) 2009; 27 KK Hsu (ref8) 2010; 29 ML Oliveira (ref9) 2010; 5 |
References_xml | – volume: 27 start-page: 4219 year: 2009 ident: ref5 article-title: Bordetella pertussis monophosphoryl lipid A as adjuvant for inactivated split virion influenza vaccine in mice. publication-title: Vaccine doi: 10.1016/j.vaccine.2009.04.047 contributor: fullname: W Quintilio – year: 2009 ident: ref12 article-title: Guia de Vigilância Epidemiológica. Brasília: Ministério da Saúde. contributor: fullname: MS Brasil – volume: 5 start-page: e10863 year: 2010 ident: ref9 article-title: Combination of pneumococcal surface protein A (PspA) with whole cell pertussis vaccine increases protection against pneumococcal challenge in mice. publication-title: PLoS ONE doi: 10.1371/journal.pone.0010863 contributor: fullname: ML Oliveira – volume: 28 start-page: 2505 year: 2010 ident: ref4 article-title: Production of H5N1 (NIBRG-14) inactivated whole virus and split virion influenza vaccines and analysis of immunogenicity in mice using different adjuvant formulations. publication-title: Vaccine doi: 10.1016/j.vaccine.2010.01.044 contributor: fullname: C Miyaki – volume: 27 start-page: C22 year: 2009 ident: ref7 article-title: Serotype replacement in perspective. publication-title: Vaccine doi: 10.1016/j.vaccine.2009.06.004 contributor: fullname: R Dagan – volume: 29 start-page: A12 year: 2011 ident: ref1 article-title: Influenza vaccine production for Brazil: A classic example of successful Noth-South bilateral technology transfer. publication-title: Vaccine doi: 10.1016/j.vaccine.2011.04.127 contributor: fullname: C Miyaki – volume: 64 start-page: 563 year: 2010 ident: ref11 article-title: Confidence in vaccines in developing countries: social, cultural, economic and political influences. publication-title: J Epidemiol Community Health doi: 10.1136/jech.2008.085712 contributor: fullname: K Mulholland – volume: 4 start-page: 173 year: 2005 ident: ref2 article-title: Acellular pertussis vaccines in Japan: past, present and future. publication-title: Expert Rev Vaccines doi: 10.1586/14760584.4.2.173 contributor: fullname: M Watanabe – volume: 16 start-page: 544 year: 2009 ident: ref3 article-title: Immunogenicity of a whole-cell pertussis vaccine with low lipopolysaccharide content in infants. publication-title: Clin Vaccine Immunol doi: 10.1128/CVI.00339-08 contributor: fullname: TQ Zorzeto – volume: 29 start-page: 289 year: 2010 ident: ref8 article-title: Changing serotypes causing childhood invasive pneumococcal disease: Massachusetts, 2001–2007. publication-title: Pediatr Infect Dis J doi: 10.1097/INF.0b013e3181c15471 contributor: fullname: KK Hsu – volume: 28 start-page: 2130 year: 2010 ident: ref6 article-title: The effect of routine vaccination on invasive pneumococcal infections in Canadian children, Immunization Monitoring Program, Active 2000–2007. publication-title: Vaccine doi: 10.1016/j.vaccine.2009.12.026 contributor: fullname: JA Bettinger – volume: 26 start-page: 647 year: 2008 ident: ref10 article-title: Immunogenicity and safety of combined intradermal recombinant Hepatitis B with BCG vaccines at birth. publication-title: Vaccine doi: 10.1016/j.vaccine.2007.11.048 contributor: fullname: EF Carniel |
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The companies are understandably reluctant to create competitors with knowledge and capabilities in the most up-to-date production methods and most advanced... |
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Title | Economical value of vaccines for the developing countries--the case of Instituto Butantan, a public institution in Brazil |
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