Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure

• Published in: BMC medicine Vol. 22; no. 1; pp. 95 - 17
• Main Authors: Hassan, Hozeifa Mohamed, Liang, Xi, Xin, Jiaojiao, Lu, Yingyan, Cai, Qun, Shi, Dongyan, Ren, Keke, Li, Jun, Chen, Qi, Li, Jiang, Li, Peng, Guo, Beibei, Yang, Hui, Luo, Jinjin, Yao, Heng, Zhou, Xingping, Hu, Wen, Jiang, Jing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.03.2024; BioMed Central; BMC
• Subjects: Acute-On-Chronic Liver Failure; Analysis; Animals; Apoptosis; Biological markers; Biomarkers; Care and treatment; Cirrhosis; Development and progression; Enzyme-linked immunosorbent assay; Enzymes; Genes; Health aspects; Hepatitis; Hepatitis B; Hepatitis B virus; Hepatocellular apoptosis; Humans; Immune response; Immune system; Immune-metabolism disorder; Inflammation; Inflammatory response; Leukocytes, Mononuclear; Liver; Liver cancer; Liver Cirrhosis; Liver diseases; Liver failure; Liver transplants; Medical prognosis; Metabolism; Mice; Molecular mechanics; Mortality; Pathogenesis; Pathogens; Peripheral blood mononuclear cells; Phenotype; Polymerase chain reaction; Prospective Studies; Rats; Risk factors; Severity prediction; Survival analysis; Thrombospondin; Thrombospondin 1; Thrombospondin 1 - genetics; Transcriptomes; China; United States > US; Acute-on-chronic liver failure; Inflammatory response; Immune-metabolism disorder; Thrombospondin 1; Hepatocellular apoptosis; Severity prediction

The key role of thrombospondin 1 (THBS1) in the pathogenesis of acute-on-chronic liver failure (ACLF) is unclear. Here, we present a transcriptome approach to evaluate THBS1 as a potential biomarker in ACLF disease pathogenesis. Biobanked peripheral blood mononuclear cells (PBMCs) from 330 subjects...