Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure - Hassan, Hozeifa Mohamed; Liang, Xi; Xin, Jiaojiao; Lu, Yingyan; Cai, Qun; Shi, Dongyan; Ren, Keke; Li, Jun; Chen, Qi; Li, Jiang; Li, Peng; Guo, Beibei; et al. (BMC medicine, 2024)
Keywords: Acute-On-Chronic Liver Failure; Analysis; Animals; Apoptosis; Biological markers; Biomarkers; Care and treatment; Cirrhosis; Development and progression; Enzyme-linked immunosorbent assay; Enzymes; Genes; Health aspects; Hepatitis; Hepatitis B; Hepatitis B virus; Hepatocellular apoptosis; Humans; Immune response; Immune system; Immune-metabolism disorder; Inflammation; Inflammatory response; Leukocytes, Mononuclear; Liver; Liver cancer; Liver Cirrhosis; Liver diseases; Liver failure; Liver transplants; Medical prognosis; Metabolism; Mice; Molecular mechanics; Mortality; Pathogenesis; Pathogens; Peripheral blood mononuclear cells; Phenotype; Polymerase chain reaction; Prospective Studies; Rats; Risk factors; Severity prediction; Survival analysis; Thrombospondin; Thrombospondin 1; Thrombospondin 1 - genetics; Transcriptomes; China; United States--US; Acute-on-chronic liver failure; Inflammatory response; Immune-metabolism disorder; Thrombospondin 1; Hepatocellular apoptosis; Severity prediction