The E3 ligase NEURL3 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma by promoting vimentin degradation

• Published in: Journal of experimental & clinical cancer research Vol. 43; no. 1; pp. 14 - 16
• Main Authors: Zhou, Shi-Qing, Feng, Ping, Ye, Ming-Liang, Huang, Sheng-Yan, He, Shi-Wei, Zhu, Xun-Hua, Chen, Jun, Zhang, Qun, Li, Ying-Qing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.01.2024; BioMed Central; BMC
• Subjects: Antibodies; Cancer; Cancer therapies; Carcinoma; Cells; Datasets; DNA methylation; Epithelial-Mesenchymal Transition; Genomes; Health aspects; Humans; Immunohistochemistry; Ligases; Metastasis; Methylation; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - genetics; Nasopharyngeal Neoplasms - genetics; NEURL3; Plasmids; Proteins; Stem cells; Throat cancer; Tumorigenesis; Ubiquitin; Ubiquitin-Protein Ligases - genetics; Vimentin; Vimentin - genetics; Wound healing; China; United States > US; Nasopharyngeal carcinoma; Vimentin; DNA methylation; Metastasis; NEURL3

Metastasis has emerged as the major reason of treatment failure and mortality in patients with nasopharyngeal carcinoma (NPC). Growing evidence links abnormal DNA methylation to the initiation and progression of NPC. However, the precise regulatory mechanism behind these processes remains poorly und...