SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

• Published in: Cell reports (Cambridge) Vol. 20; no. 8; pp. 1921 - 1935
• Main Authors: Daddacha, Waaqo, Koyen, Allyson E., Bastien, Amanda J., Head, PamelaSara E., Dhere, Vishal R., Nabeta, Geraldine N., Connolly, Erin C., Werner, Erica, Madden, Matthew Z., Daly, Michele B., Minten, Elizabeth V., Whelan, Donna R., Schlafstein, Ashley J., Zhang, Hui, Anand, Roopesh, Doronio, Christine, Withers, Allison E., Shepard, Caitlin, Sundaram, Ranjini K., Deng, Xingming, Dynan, William S., Wang, Ya, Bindra, Ranjit S., Cejka, Petr, Rothenberg, Eli, Doetsch, Paul W., Kim, Baek, Yu, David S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.08.2017; Elsevier
• Subjects: AGS; autoimmune; CLL; CtIP; DNA Breaks, Double-Stranded; DNA damage response; DNA end resection; DNA End-Joining Repair; DNA repair; dNTP; HCT116 Cells; HEK293 Cells; HeLa Cells; HIV; Homologous Recombination; Humans; MCF-7 Cells; SAM Domain and HD Domain-Containing Protein 1 - deficiency; SAM Domain and HD Domain-Containing Protein 1 - genetics; SAM Domain and HD Domain-Containing Protein 1 - metabolism; Transfection; CLL; HIV; homologous recombination; autoimmune; DNA damage response; CtIP; dNTP; DNA repair; DNA end resection; AGS

DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associated with Aicardi-Goutières syndrome and cancer. We s...