Tumor Necrosis Factor-α Induces Skeletal Muscle Insulin Resistance in Healthy Human Subjects via Inhibition of Akt Substrate 160 Phosphorylation - Plomgaard, Peter; Bouzakri, Karim; Krogh-Madsen, Rikke; Mittendorfer, Bettina; Zierath, Juleen R.; Pedersen, Bente K. (Diabetes (New York, N.Y.), 2005)
Keywords: Adult; Biological and medical sciences; Care and treatment; Deuterium; Diabetes. Impaired glucose tolerance; Drug Resistance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fundamental and applied biological sciences. Psychology; Glucose - biosynthesis; Glucose - metabolism; Glucose Clamp Technique; GTPase-Activating Proteins - metabolism; Health aspects; Humans; Insulin - blood; Insulin - pharmacology; Insulin resistance; Liver - drug effects; Liver - metabolism; Male; Medical sciences; Muscle, Skeletal - drug effects; Obesity; Phosphorylation; Placebos; Recombinant Proteins; Risk factors; Signal Transduction - drug effects; Striated muscle. Tendons; Tumor necrosis factor; Tumor Necrosis Factor-alpha - analysis; Tumor Necrosis Factor-alpha - pharmacology; Vertebrates: osteoarticular system, musculoskeletal system; United Kingdom; Endocrinopathy; Human; Phosphorylation; Diabetes mellitus; Cytokine; Insulin resistance; Inhibition; Striated muscle; Tumor necrosis factor α