Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity

• Published in: Cell reports (Cambridge) Vol. 31; no. 13; p. 107818
• Main Authors: Han, Chang Yeop, Kang, Inkyung, Harten, Ingrid A., Gebe, John A., Chan, Christina K., Omer, Mohamed, Alonge, Kimberly M., den Hartigh, Laura J., Gomes Kjerulf, Diego, Goodspeed, Leela, Subramanian, Savitha, Wang, Shari, Kim, Francis, Birk, David E., Wight, Thomas N., Chait, Alan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.06.2020; Elsevier
• Subjects: 3T3-L1 Cells; Adipocytes - metabolism; Adipose Tissue - pathology; adipose tissue inflammation; Animals; biglycan; Biglycan - metabolism; Bone Marrow - metabolism; Diet, High-Fat; Female; Glucose Tolerance Test; Humans; Hypertrophy; Inflammation - pathology; Insulin Resistance; Liver - pathology; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Middle Aged; obesity; Obesity - pathology; Omentum - metabolism; Organ Specificity; proteoglycans; RNA, Messenger - genetics; RNA, Messenger - metabolism; Subcutaneous Fat - pathology; versican; Versicans - genetics; Versicans - metabolism; proteoglycans; versican; biglycan; adipose tissue inflammation; insulin resistance; obesity

Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obesity. Versican is produced mainly by adipocytes and biglyca...