Th17/Treg ratio in human graft-versus-host disease

• Published in: Blood Vol. 116; no. 7; pp. 1165 - 1171
• Main Authors: Ratajczak, Philippe, Janin, Anne, Peffault de Latour, Regis, Leboeuf, Christophe, Desveaux, Allison, Keyvanfar, Keyvan, Robin, Marie, Clave, Emmanuel, Douay, Corine, Quinquenel, Anne, Pichereau, Claire, Bertheau, Philippe, Mary, Jean Yves, Socié, Gérard
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 19.08.2010; Americain Society of Hematology; American Society of Hematology
• Subjects: Adult; Biological and medical sciences; Cancer; Cohort Studies; Female; Graft vs Host Disease; Graft vs Host Disease - immunology; Graft vs Host Disease - metabolism; Hematologic and hematopoietic diseases; Hematologic Neoplasms; Hematologic Neoplasms - immunology; Hematologic Neoplasms - metabolism; Hematologic Neoplasms - therapy; Humans; Interleukin-17; Interleukin-17 - immunology; Interleukin-17 - metabolism; Life Sciences; Male; Medical sciences; Middle Aged; Prognosis; Skin Diseases; Skin Diseases - immunology; Skin Diseases - metabolism; Skin Diseases - therapy; T-Lymphocytes, Regulatory; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha - metabolism; Human; Immunopathology; Graft versus host disease; Hematology; Stem cell; Hematopoietic cell; Homograft; Graft; Th17 lymphocyte

Th17 cells have never been explored in human graft-versus-host disease (GVHD). We studied the correlation between the presence of Th17 cells with histologic and clinical parameters. We first analyzed a cohort of 40 patients with GVHD of the gastrointestinal tract. Tumor necrosis factor (TNF), TNF re...