CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect

• Published in: Journal of experimental & clinical cancer research Vol. 42; no. 1; pp. 63 - 22
• Main Authors: Zheng, Jun, Yan, Xijing, Lu, Tongyu, Song, Wen, Li, Yang, Liang, Jinliang, Zhang, Jiebin, Cai, Jianye, Sui, Xin, Xiao, Jiaqi, Chen, Haitian, Chen, Guihua, Zhang, Qi, Liu, Yubin, Yang, Yang, Zheng, Kanghong, Pan, Zihao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.03.2023; BioMed Central; BMC
• Subjects: Animals; Apoptosis; Cancer therapies; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Cell Proliferation - genetics; Circular RNA; Dehydrogenases; Development and progression; Encoding capacity; Flow cytometry; Gene expression; Gene Expression Regulation, Neoplastic; Glucose metabolism; Hepatocellular carcinoma; Hepatoma; Humans; Hybridization; Kinases; Liver; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Medical prognosis; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA sponge; Phosphorylation; Physiological aspects; Prognosis; Proteins; RNA; RNA, Circular - genetics; The Warburg effect; Massachusetts; China; Germany; United States > US; The Warburg effect; miRNA sponge; Circular RNA; Hepatocellular carcinoma; Encoding capacity

The Warburg effect is well-established to be essential for tumor progression and accounts for the poor clinical outcomes of hepatocellular carcinoma (HCC) patients. An increasing body of literature suggests that circular RNAs (circRNAs) are important regulators for HCC. However, few circRNAs involve...