Dual RNA-Seq of Mtb-Infected Macrophages In Vivo Reveals Ontologically Distinct Host-Pathogen Interactions

• Published in: Cell reports (Cambridge) Vol. 30; no. 2; pp. 335 - 350.e4
• Main Authors: Pisu, Davide, Huang, Lu, Grenier, Jennifer K., Russell, David G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.01.2020; Elsevier
• Subjects: alveolar macrophage; Animals; dual RNA-seq; Host-Pathogen Interactions; Humans; interstitial macrophage; Lung - pathology; macrophage; Macrophages - microbiology; Mice; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; nutritional immunity; RNA-Seq - methods; tuberculosis; interstitial macrophage; alveolar macrophage; Mycobacterium tuberculosis; nutritional immunity; dual RNA-seq; tuberculosis; macrophage

Dissecting the in vivo host-pathogen interplay is crucial to understanding the molecular mechanisms governing control or progression of intracellular infections. In this work, we explore the in vivo molecular dynamics of Mtb infection by performing dual RNA-seq on Mycobacterium tuberculosis-infected...