Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients

• Published in: EBioMedicine Vol. 2; no. 12; pp. 2080 - 2086
• Main Authors: Hoan, Nghiem Xuan, Tong, Hoang Van, Hecht, Nicole, Sy, Bui Tien, Marcinek, Patrick, Meyer, Christian G., Song, Le Huu, Toan, Nguyen Linh, Kurreck, Jens, Kremsner, Peter G., Bock, C-Thomas, Velavan, Thirumalaisamy P.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2015; Elsevier
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Child; Coinfection; Cross-Sectional Studies; Female; Genotype; HBV infection; HBV-related liver diseases; Hepatitis Antibodies; Hepatitis B - complications; Hepatitis B - epidemiology; Hepatitis B - virology; Hepatitis B virus - physiology; Hepatitis E - complications; Hepatitis E - epidemiology; Hepatitis E - virology; Hepatitis E virus; Hepatitis E virus - physiology; HEV seroprevalence; HEV superinfection; Humans; Liver Cirrhosis - epidemiology; Liver Cirrhosis - etiology; Liver Neoplasms - epidemiology; Liver Neoplasms - etiology; Male; Middle Aged; Patient Outcome Assessment; Prevalence; RNA, Viral; Seroepidemiologic Studies; Superinfection; Vietnam - epidemiology; Young Adult; ORF; AST; HEV superinfection; IgG; HBV-related liver diseases; HCC; ALT; AFP; IgM; Hepatitis E virus; HEV seroprevalence; RBC; HBV infection; LC; HEV; WBC; PLT; AHB; CHB; HBV; HBV, hepatitis B virus; IgM, immunoglobulin M; LC, liver cirrhosis; ORF, open reading frame; RBC, red blood cells; WBC, white blood cells; ALT, alanine amino transferase; CHB, chronic hepatitis B; IgG, immunoglobulin G; AHB, acute hepatitis B; AFP, alpha-feto protein; AST, aspartate amino transferase; HEV, hepatitis E virus; HCC, hepatocellular carcinoma; PLT, platelets

Hepatitis E virus (HEV) infection may cause acute hepatitis and lead to hepatic failure in developing and developed countries. We studied HEV seroprevalences in patients with hepatitis B virus (HBV) infection to understand the consequences of HEV superinfection in a Vietnamese population. This cross...