Phytochemical Induction of Cell Cycle Arrest by Glutathione Oxidation and Reversal by N-Acetylcysteine in Human Colon Carcinoma Cells

• Published in: Nutrition and cancer Vol. 61; no. 3; pp. 332 - 339
• Main Authors: Odom, R.Y, Dansby, M.Y, Rollins-Hairston, A.M, Jackson, K.M, Kirlin, W.G
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Taylor & Francis Group 07.05.2009; Taylor& Francis
• Subjects: acetylcysteine; Acetylcysteine - pharmacology; Allyl Compounds - pharmacology; Anticarcinogenic Agents - pharmacology; benzyl isothiocyanate; Biological and medical sciences; buthione sulfoxamine; Butyrates - pharmacology; Carotenoids - pharmacology; cell cycle; Cell Cycle - drug effects; cell growth; cell proliferation; Cell Proliferation - drug effects; colorectal neoplasms; diallyl disulfide; Dimethyl Fumarate; disease prevention; Disulfides - pharmacology; Feeding. Feeding behavior; Fumarates - pharmacology; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; glutathione; Glutathione - metabolism; HT29 Cells; human diseases; Humans; inhibitors; intracellular glutathione; Isothiocyanates - pharmacology; Lycopene; Medical sciences; N-acetylcysteine; oxidation; Oxidation-Reduction; phytochemicals; Plants - chemistry; redox potential; sodium butyrate; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Phytochemical compound; Human; Thiol; Induction; Acetylcysteine; Malignant tumor; Colonic disease; Mucolytic; Cancerology; Cell cycle; Digestive diseases; Intestinal disease; Oxidation; Colon carcinoma; Cell; Cancer; Glutathione

Cancer prevention by dietary phytochemicals has been shown to involve decreased cell proliferation and cell cycle arrest. However, there is limited understanding of the mechanisms involved. Previously, we have shown that a common effect of phytochemicals investigated is to oxidize the intracellular...