The Molecular Structure and Catalytic Mechanism of a Quorum-Quenching N-Acyl-L-Homoserine Lactone Hydrolase

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 49; pp. 17606 - 17611
• Main Authors: Myung Hee Kim, Won-Chan Choi, Hye Ok Kang, Jong Suk Lee, Beom Sik Kang, Kyung-Jin Kim, Zygmunt S. Derewenda, Tae-Kwang Oh, Choong Hwan Lee, Lee, Jung-Kee
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 06.12.2005; National Acad Sciences
• Subjects: Atoms; Bacillus thuringiensis; Bacillus thuringiensis - enzymology; Bacillus thuringiensis - genetics; Bacteria; Binding Sites; Biochemistry; Biofilms; Biological Sciences; Carboxylic Ester Hydrolases - chemistry; Carboxylic Ester Hydrolases - genetics; Carboxylic Ester Hydrolases - metabolism; Catalysis; Cations, Divalent - chemistry; Crystal structure; Enzyme substrates; Enzymes; Erwinia carotovora; Hydrogen bonds; Ions; Lactones; Models, Molecular; Molecules; Mutation - genetics; Oxygen; Protein Structure, Tertiary; Pseudomonas aeruginosa; Substrate Specificity; Zinc; Zinc - chemistry; Zinc - metabolism

In many Gram-negative bacteria, including a number of pathogens such as Pseudomonas aeruginosa and Erwinia carotovora, virulence factor production and biofilm formation are linked to the quorum-sensing systems that use diffusible N-acyl-L-homoserine lactones (AHLs) as intercellular messenger molecul...