Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine - Poursaitidis, Ioannis; Wang, Xiaomeng; Crighton, Thomas; Labuschagne, Christiaan; Mason, David; Cramer, Shira L.; Triplett, Kendra; Roy, Rajat; Pardo, Olivier E.; Seckl, Michael J.; Rowlinson, Scott W.; Stone, Everett; et al. (Cell reports (Cambridge), 2017)
Keywords: Amino Acids - metabolism; Animals; Breast - cytology; Carcinoma, Non-Small-Cell Lung - pathology; Cell Death - drug effects; Cell Line, Tumor; Cell Survival - drug effects; Cysteine - metabolism; Cystine - pharmacology; Down-Regulation - drug effects; EGFR; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Female; ferroptosis; Glutathione - pharmacology; Glutathione Peroxidase - metabolism; GPX4; Hydrogen Peroxide - metabolism; Iron - metabolism; Lung Neoplasms - pathology; MAP Kinase Signaling System - drug effects; MAPK; Mice, SCID; Mutation - genetics; NOX4; oncogene; Oncogenes; Receptor, Epidermal Growth Factor - genetics; ROS; ferroptosis; GPX4; ROS; NOX4; oncogene; MAPK; EGFR