Metabolic reprogramming in the tumor microenvironment of liver cancer

The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic rearrangements. Overwhelming evidence has illustrated that dysregulated cellular metabolism can, in turn, promote anabolic growth and tumor propagatio...

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Published inJournal of hematology and oncology Vol. 17; no. 1; pp. 6 - 19
Main Authors Lin, Jian, Rao, Dongning, Zhang, Mao, Gao, Qiang
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 31.01.2024
BioMed Central
BMC
Subjects
Amino acids
Cancer therapies
Cholesterol
Dehydrogenases
Development and progression
Drug resistance
Fatty acids
Glucose
Gut–liver axis
Health aspects
Hepatocytes
Homeostasis
Hypoxia
Immune microenvironment
Immune response
Immunosurveillance
Immunotherapy
Kinases
Lipids
Liver cancer
Medical prognosis
Metabolic reprogramming
Metabolism
Metabolites
Metastasis
Patients
Physiological aspects
Proteomics
Remission
Review
Risk factors
Tumor microenvironment
Tumors
Immune microenvironment
Liver cancer
Gut–liver axis
Metabolic reprogramming
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Abstract The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic rearrangements. Overwhelming evidence has illustrated that dysregulated cellular metabolism can, in turn, promote anabolic growth and tumor propagation in a hostile microenvironment. In addition to supporting continuous tumor growth and survival, disrupted metabolic process also creates obstacles for the anticancer immune response and restrains durable clinical remission following immunotherapy. In this review, we elucidate the metabolic communication between liver cancer cells and their surrounding immune cells and discuss how metabolic reprogramming of liver cancer impacts the immune microenvironment and the efficacy of anticancer immunotherapy. We also describe the crucial role of the gut–liver axis in remodeling the metabolic crosstalk of immune surveillance and escape, highlighting novel therapeutic opportunities.
AbstractList The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic rearrangements. Overwhelming evidence has illustrated that dysregulated cellular metabolism can, in turn, promote anabolic growth and tumor propagation in a hostile microenvironment. In addition to supporting continuous tumor growth and survival, disrupted metabolic process also creates obstacles for the anticancer immune response and restrains durable clinical remission following immunotherapy. In this review, we elucidate the metabolic communication between liver cancer cells and their surrounding immune cells and discuss how metabolic reprogramming of liver cancer impacts the immune microenvironment and the efficacy of anticancer immunotherapy. We also describe the crucial role of the gut-liver axis in remodeling the metabolic crosstalk of immune surveillance and escape, highlighting novel therapeutic opportunities.
The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic rearrangements. Overwhelming evidence has illustrated that dysregulated cellular metabolism can, in turn, promote anabolic growth and tumor propagation in a hostile microenvironment. In addition to supporting continuous tumor growth and survival, disrupted metabolic process also creates obstacles for the anticancer immune response and restrains durable clinical remission following immunotherapy. In this review, we elucidate the metabolic communication between liver cancer cells and their surrounding immune cells and discuss how metabolic reprogramming of liver cancer impacts the immune microenvironment and the efficacy of anticancer immunotherapy. We also describe the crucial role of the gut-liver axis in remodeling the metabolic crosstalk of immune surveillance and escape, highlighting novel therapeutic opportunities.The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic rearrangements. Overwhelming evidence has illustrated that dysregulated cellular metabolism can, in turn, promote anabolic growth and tumor propagation in a hostile microenvironment. In addition to supporting continuous tumor growth and survival, disrupted metabolic process also creates obstacles for the anticancer immune response and restrains durable clinical remission following immunotherapy. In this review, we elucidate the metabolic communication between liver cancer cells and their surrounding immune cells and discuss how metabolic reprogramming of liver cancer impacts the immune microenvironment and the efficacy of anticancer immunotherapy. We also describe the crucial role of the gut-liver axis in remodeling the metabolic crosstalk of immune surveillance and escape, highlighting novel therapeutic opportunities.
The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic rearrangements. Overwhelming evidence has illustrated that dysregulated cellular metabolism can, in turn, promote anabolic growth and tumor propagation in a hostile microenvironment. In addition to supporting continuous tumor growth and survival, disrupted metabolic process also creates obstacles for the anticancer immune response and restrains durable clinical remission following immunotherapy. In this review, we elucidate the metabolic communication between liver cancer cells and their surrounding immune cells and discuss how metabolic reprogramming of liver cancer impacts the immune microenvironment and the efficacy of anticancer immunotherapy. We also describe the crucial role of the gut-liver axis in remodeling the metabolic crosstalk of immune surveillance and escape, highlighting novel therapeutic opportunities. Keywords: Liver cancer, Metabolic reprogramming, Immune microenvironment, Gut-liver axis
Abstract The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic rearrangements. Overwhelming evidence has illustrated that dysregulated cellular metabolism can, in turn, promote anabolic growth and tumor propagation in a hostile microenvironment. In addition to supporting continuous tumor growth and survival, disrupted metabolic process also creates obstacles for the anticancer immune response and restrains durable clinical remission following immunotherapy. In this review, we elucidate the metabolic communication between liver cancer cells and their surrounding immune cells and discuss how metabolic reprogramming of liver cancer impacts the immune microenvironment and the efficacy of anticancer immunotherapy. We also describe the crucial role of the gut–liver axis in remodeling the metabolic crosstalk of immune surveillance and escape, highlighting novel therapeutic opportunities.
ArticleNumber 6
Audience Academic
Author Rao, Dongning
Gao, Qiang
Lin, Jian
Zhang, Mao
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Issue 1
Keywords Immune microenvironment
Liver cancer
Gut–liver axis
Metabolic reprogramming
Language English
License 2024. The Author(s).
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Snippet The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic...
Abstract The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic...
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SubjectTerms Amino acids
Cancer therapies
Cholesterol
Dehydrogenases
Development and progression
Drug resistance
Fatty acids
Glucose
Gut–liver axis
Health aspects
Hepatocytes
Homeostasis
Hypoxia
Immune microenvironment
Immune response
Immunosurveillance
Immunotherapy
Kinases
Lipids
Liver cancer
Medical prognosis
Metabolic reprogramming
Metabolism
Metabolites
Metastasis
Patients
Physiological aspects
Proteomics
Remission
Review
Risk factors
Tumor microenvironment
Tumors
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Title Metabolic reprogramming in the tumor microenvironment of liver cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/38297372
https://www.proquest.com/docview/2925654918
https://www.proquest.com/docview/2921116221
https://pubmed.ncbi.nlm.nih.gov/PMC10832230
https://doaj.org/article/9b52e7aaa08f47c6987162ed107d9a5d
Volume 17
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