Mechanism of mRNA Transport in the Nucleus

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 47; pp. 17008 - 17013
• Main Authors: Diana Y. Vargas, Arjun Raj, Salvatore A. E. Marras, Kramer, Fred Russell, Tyagi, Sanjay
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.11.2005; National Acad Sciences
• Subjects: Active Transport, Cell Nucleus; Adenosine Triphosphate - metabolism; Animals; Beacons; Biological Sciences; Cell lines; Cell Nucleus - metabolism; Cellular biology; CHO Cells; Chromatin; Cold Temperature; Cricetinae; Cricetulus; Diffusion; Fluorescence; Gene expression; Genes, Reporter; Messenger RNA; Molecules; Particle diffusion; Particle intensity; Proteins; Ribonucleic acid; Ribonucleoproteins - metabolism; RNA; RNA, Messenger - metabolism

The mechanism of transport of mRNA-protein (mRNP) complexes from transcription sites to nuclear pores has been the subject of many studies. Using molecular beacons to track single mRNA molecules in living cells, we have characterized the diffusion of mRNP complexes in the nucleus. The mRNP complexes...