Spatial multi-omics: deciphering technological landscape of integration of multi-omics and its applications

The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context among cell populations. Integrated analysis of the genome, transcriptome, proteome, metabolome, and epigenome has enhanced our understanding of cell bio...

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Published inJournal of hematology and oncology Vol. 17; no. 1; pp. 72 - 24
Main Authors Liu, Xiaojie, Peng, Ting, Xu, Miaochun, Lin, Shitong, Hu, Bai, Chu, Tian, Liu, Binghan, Xu, Yashi, Ding, Wencheng, Li, Li, Cao, Canhui, Wu, Peng
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 24.08.2024
BioMed Central
BMC
Subjects
Accuracy
Animals
Bar codes
Biological analysis
Cancer research
Cancer therapies
Cells
Crosstalk
Developmental biology
Efficiency
Gene expression
Genomes
Genomic analysis
Genomics
Genomics - methods
Heterogeneity
Humans
Hybridization
Lineage tracking
Localization
Medical research
Metabolites
Metabolomics - methods
Methods
Molecular modelling
Multiomics
Neoplasms - genetics
New therapy
Proteomes
Proteomics - methods
Review
Spatial heterogeneity
Spatial multi-omics
Spatial-specific atlas
Technology
Transcriptomes
Heterogeneity
Spatial-specific atlas
Reproduction
Spatial multi-omics
Lineage tracking
New therapy
Crosstalk
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Abstract The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context among cell populations. Integrated analysis of the genome, transcriptome, proteome, metabolome, and epigenome has enhanced our understanding of cell biology and the molecular basis of human diseases. Moreover, this approach offers profound insights into the interactions between intracellular and intercellular molecular mechanisms involved in the development, physiology, and pathogenesis of human diseases. In this comprehensive review, we examine current advancements in multi-omics technologies, focusing on their evolution and refinement over the past decade, including improvements in throughput and resolution, modality integration, and accuracy. We also discuss the pivotal contributions of spatial multi-omics in revealing spatial heterogeneity, constructing detailed spatial atlases, deciphering spatial crosstalk in tumor immunology, and advancing translational research and cancer therapy through precise spatial mapping.
AbstractList Abstract The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context among cell populations. Integrated analysis of the genome, transcriptome, proteome, metabolome, and epigenome has enhanced our understanding of cell biology and the molecular basis of human diseases. Moreover, this approach offers profound insights into the interactions between intracellular and intercellular molecular mechanisms involved in the development, physiology, and pathogenesis of human diseases. In this comprehensive review, we examine current advancements in multi-omics technologies, focusing on their evolution and refinement over the past decade, including improvements in throughput and resolution, modality integration, and accuracy. We also discuss the pivotal contributions of spatial multi-omics in revealing spatial heterogeneity, constructing detailed spatial atlases, deciphering spatial crosstalk in tumor immunology, and advancing translational research and cancer therapy through precise spatial mapping.
The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context among cell populations. Integrated analysis of the genome, transcriptome, proteome, metabolome, and epigenome has enhanced our understanding of cell biology and the molecular basis of human diseases. Moreover, this approach offers profound insights into the interactions between intracellular and intercellular molecular mechanisms involved in the development, physiology, and pathogenesis of human diseases. In this comprehensive review, we examine current advancements in multi-omics technologies, focusing on their evolution and refinement over the past decade, including improvements in throughput and resolution, modality integration, and accuracy. We also discuss the pivotal contributions of spatial multi-omics in revealing spatial heterogeneity, constructing detailed spatial atlases, deciphering spatial crosstalk in tumor immunology, and advancing translational research and cancer therapy through precise spatial mapping.
The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context among cell populations. Integrated analysis of the genome, transcriptome, proteome, metabolome, and epigenome has enhanced our understanding of cell biology and the molecular basis of human diseases. Moreover, this approach offers profound insights into the interactions between intracellular and intercellular molecular mechanisms involved in the development, physiology, and pathogenesis of human diseases. In this comprehensive review, we examine current advancements in multi-omics technologies, focusing on their evolution and refinement over the past decade, including improvements in throughput and resolution, modality integration, and accuracy. We also discuss the pivotal contributions of spatial multi-omics in revealing spatial heterogeneity, constructing detailed spatial atlases, deciphering spatial crosstalk in tumor immunology, and advancing translational research and cancer therapy through precise spatial mapping.The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context among cell populations. Integrated analysis of the genome, transcriptome, proteome, metabolome, and epigenome has enhanced our understanding of cell biology and the molecular basis of human diseases. Moreover, this approach offers profound insights into the interactions between intracellular and intercellular molecular mechanisms involved in the development, physiology, and pathogenesis of human diseases. In this comprehensive review, we examine current advancements in multi-omics technologies, focusing on their evolution and refinement over the past decade, including improvements in throughput and resolution, modality integration, and accuracy. We also discuss the pivotal contributions of spatial multi-omics in revealing spatial heterogeneity, constructing detailed spatial atlases, deciphering spatial crosstalk in tumor immunology, and advancing translational research and cancer therapy through precise spatial mapping.
The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context among cell populations. Integrated analysis of the genome, transcriptome, proteome, metabolome, and epigenome has enhanced our understanding of cell biology and the molecular basis of human diseases. Moreover, this approach offers profound insights into the interactions between intracellular and intercellular molecular mechanisms involved in the development, physiology, and pathogenesis of human diseases. In this comprehensive review, we examine current advancements in multi-omics technologies, focusing on their evolution and refinement over the past decade, including improvements in throughput and resolution, modality integration, and accuracy. We also discuss the pivotal contributions of spatial multi-omics in revealing spatial heterogeneity, constructing detailed spatial atlases, deciphering spatial crosstalk in tumor immunology, and advancing translational research and cancer therapy through precise spatial mapping. Keywords: Spatial multi-omics, Heterogeneity, Spatial-specific atlas, Lineage tracking, Crosstalk, New therapy, Reproduction
ArticleNumber 72
Audience Academic
Author Li, Li
Liu, Binghan
Liu, Xiaojie
Xu, Miaochun
Cao, Canhui
Peng, Ting
Ding, Wencheng
Hu, Bai
Chu, Tian
Xu, Yashi
Wu, Peng
Lin, Shitong
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Cites_doi 10.1038/s41586-022-05094-1
10.1038/s41586-023-05706-4
10.1016/j.it.2024.02.007
10.1038/s41586-021-04217-4
10.1016/j.xpro.2021.100532
10.1186/s40779-023-00471-x
10.1093/nar/gkx1206
10.1038/s41587-020-0739-1
10.1016/j.jep.2018.02.003
10.1038/s41592-023-01884-1
10.1186/s12943-024-02040-9
10.1016/j.neuron.2016.10.001
10.1016/j.jpha.2023.11.017
10.1021/ac202450g
10.1016/j.cell.2022.10.014
10.1186/s13059-022-02824-6
10.1038/s41586-019-1907-7
10.1016/j.cell.2018.05.035
10.3390/ijms17060816
10.1186/s13287-020-01941-y
10.1002/advs.202206939
10.1038/nmeth.4380
10.1038/s41467-021-23807-4
10.1126/science.abg7216
10.1002/advs.202306515
10.15252/msb.202010108
10.1038/s41585-020-00400-w
10.1016/j.canlet.2012.11.025
10.1093/humupd/dmad017
10.1016/j.cell.2022.09.035
10.1038/s41586-023-06806-x
10.1016/j.tig.2014.07.001
10.1186/1471-2164-12-245
10.1038/nrm3314
10.1126/science.1250212
10.1038/s41586-023-05869-0
10.1038/s41467-022-28445-y
10.1038/s41467-024-45665-6
10.1038/nmeth.1448
10.1038/s41467-021-21615-4
10.1016/j.cmet.2022.02.010
10.1007/s13238-020-00757-z
10.1038/nmeth.2563
10.1038/s41592-021-01197-1
10.1515/mr-2023-0046
10.1016/j.gpb.2022.10.001
10.1155/2012/251364
10.1038/nature03959
10.1039/c1mb05350g
10.1016/j.csbj.2016.02.005
10.1371/journal.pcbi.1005839
10.1111/tra.12310
10.1038/s41592-023-02110-8
10.1038/nprot.2014.191
10.1016/j.molcel.2015.04.021
10.1016/j.devcel.2022.04.006
10.1038/s41580-022-00572-w
10.1038/s41568-021-00336-2
10.1126/science.aaw1219
10.1038/nbt1485
10.1111/j.1440-1843.2010.01899.x
10.1007/978-1-0716-2521-7_10
10.1038/s41586-021-03634-9
10.1016/j.cell.2020.10.026
10.1126/science.aaa6090
10.1038/s41467-022-34208-6
10.1038/s41418-023-01213-1
10.1038/s41580-018-0094-y
10.21203/rs.3.rs-1499315/v1
10.1016/j.ccell.2023.01.009
10.1016/j.xgen.2022.100165
10.1038/s41587-023-01937-y
10.1038/s41592-021-01107-5
10.1016/j.tibtech.2020.05.006
10.1016/j.molcel.2018.11.035
10.1097/mnh.0000000000000988
10.1007/s10545-017-0130-7
10.1126/science.aat5691
10.3390/metabo12040357
10.1038/s41467-020-17186-5
10.1126/science.aay3446
10.1002/advs.202305724
10.1038/s41421-024-00656-1
10.1016/j.cell.2022.04.003
10.3934/genet.2017.1.47
10.3390/biom13010156
10.1021/acs.jcim.2c01161
10.1038/s41392-024-01767-7
10.1038/s41587-022-01302-5
10.1038/s41374-021-00612-7
10.1002/advs.202205395
10.2144/000113451
10.1016/j.neuron.2017.05.008
10.1016/j.cell.2019.06.024
10.1016/j.immuni.2022.11.002
10.1038/nmeth.2892
10.1038/s41576-020-0223-2
10.1016/j.immuni.2022.09.002
10.1038/s41587-019-0392-8
10.3390/life11080862
10.1126/science.abm1741
10.1038/s41576-018-0045-7
10.1021/acs.analchem.3c02029
10.1038/s41587-019-0290-0
10.1016/j.stem.2018.04.014
10.1038/s43586-021-00029-y
10.1002/mco2.315.6
10.1038/s41580-023-00615-w
10.1016/B978-0-12-381264-3.00002-3
10.1038/s41591-020-0844-1
10.1038/s41467-024-46437-y
10.3389/fonc.2022.890410
10.1016/j.ymeth.2015.12.007
10.1021/ac503092d
10.1002/0471142727.mb3002s98
10.1055/s-0039-1688446
10.1080/21541248.2017.1397833
10.1038/s41467-023-38360-5
10.1038/s41586-022-05060-x
10.1111/jcmm.18396
10.1126/sciadv.abm5500
10.1038/s43586-022-00175-x
10.1073/pnas.1912459116
10.1016/j.cell.2020.07.032
10.1186/s12929-022-00879-y
10.1038/s41586-020-03126-2
10.1038/s41551-024-01205-7
10.1016/j.tig.2018.05.008
10.1111/febs.14938
10.1016/j.cell.2024.01.021
10.1016/j.gpb.2014.09.001
10.1056/NEJMoa1616288
10.7150/thno.95908
10.1016/j.jgg.2023.02.004
10.1007/978-981-15-8104-5_1
10.1038/s41589-021-00790-x
10.1039/c8an01581c
10.3390/ijms24054992
10.1038/s41592-020-01033-y
10.1016/j.molcel.2022.05.022
10.1021/acs.jafc.3c01377
10.1038/s41587-023-01676-0
10.1038/s41568-023-00557-7
10.1016/j.tig.2022.05.010
10.1007/164_2018_103
10.1056/NEJMoa1113205
10.1186/s40246-016-0063-5
10.1186/s12943-017-0600-4
10.1016/j.xcrm.2023.101057
10.1016/j.ccell.2022.05.009
10.1016/j.devcel.2020.10.021
10.1161/CIRCRESAHA.118.310998
10.1038/s41593-023-01312-9
10.3390/ht7020009
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Issue 1
Keywords Heterogeneity
Spatial-specific atlas
Reproduction
Spatial multi-omics
Lineage tracking
New therapy
Crosstalk
Language English
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References GJ Patti (1596_CR75) 2012
K Kalhor (1596_CR15) 2024
R Cullum (1596_CR30) 2011
K Choe (1596_CR7) 2023
Y Chen (1596_CR67) 2022
X Wang (1596_CR22) 2018
A Rao (1596_CR3) 2021
J Park (1596_CR29) 2021
Y Bao (1596_CR132) 2024
S Shah (1596_CR13) 2017
T Zhao (1596_CR45) 2022
Z Li (1596_CR136) 2023
AC Dona (1596_CR73) 2016
N Rothammer (1596_CR143) 2022
E Piskadlo (1596_CR43) 2022
A Robles-Remacho (1596_CR24) 2023
M Jamal-Hanjani (1596_CR112) 2017
HJ Wu (1596_CR116) 2022
A Mund (1596_CR58) 2022
A Frede (1596_CR126) 2022
AC Payne (1596_CR47) 2021
V Marx (1596_CR4) 2021
S Hernandez (1596_CR97) 2022
M Duhamel (1596_CR118) 2022
Y Takei (1596_CR93) 2021
X Wu (1596_CR103) 2024
C Chen (1596_CR92) 2023
X Liao (1596_CR134) 2024
E Piskadlo (1596_CR10) 2022
X Chen (1596_CR25) 2018
T Wu (1596_CR144) 2024
EN Arner (1596_CR138) 2023
R Xu (1596_CR146) 2021
M Gerlinger (1596_CR115) 2012
YM Liu (1596_CR160) 2023
KD Duncan (1596_CR78) 2019
S Liu (1596_CR154) 2022
L Nguyen (1596_CR33) 2014; 35
C Larsson (1596_CR19) 2010
C Kuhl (1596_CR80) 2012
Y Jin (1596_CR6) 2024
R Ke (1596_CR16) 2013
S Shah (1596_CR157) 2018
J Xuan (1596_CR39) 2013
BAM Bouwman (1596_CR46) 2022
EL Van Dijk (1596_CR34) 2014
Y Deng (1596_CR90) 2022
NC Bauer (1596_CR51) 2015
MJ Banworth (1596_CR52) 2018
F Yang (1596_CR149) 2024
B Zhou (1596_CR76) 2012
K Bingol (1596_CR82) 2018
L Brady (1596_CR111) 2021
JM Neumann (1596_CR119) 2021
JA Christopher (1596_CR54) 2021
E Dudley (1596_CR74) 2010
R Rueedi (1596_CR83) 2017
C Neftel (1596_CR123) 2019
S Fang (1596_CR26) 2023
RJ Bridges (1596_CR53) 2018
CP Couturier (1596_CR124) 2020
A Chen (1596_CR86) 2022
C Xia (1596_CR158) 2019
L Koch (1596_CR23) 2018
Y Zhang (1596_CR127) 2020
C Kuppe (1596_CR106) 2022
SG Rodriques (1596_CR48) 2019
F Schueder (1596_CR65) 2022
NJ Mullen (1596_CR137) 2023
S Vanhorn (1596_CR129) 2021
KH Chen (1596_CR151) 2015
KC Wang (1596_CR64) 2018
NG Mahieu (1596_CR81) 2014
M Margulies (1596_CR37) 2005; 437
J Xu (1596_CR61) 2019
R Fang (1596_CR105) 2022
Y Liu (1596_CR91) 2020
A Gilles (1596_CR38) 2011
S Vickovic (1596_CR96) 2022
I Gertsman (1596_CR70) 2018
G Su (1596_CR133) 2021
MC Haffner (1596_CR110) 2021
A Arutyunyan (1596_CR107) 2023
Z Ren (1596_CR117) 2023
X Qin (1596_CR99) 2023
S Chen (1596_CR84) 2019
JH Lee (1596_CR21) 2015
P Chen (1596_CR142) 2024
C Sun (1596_CR121) 2023
Y-M Liu (1596_CR140) 2023
Y Liu (1596_CR155) 2023
R Littman (1596_CR28) 2021
S Alseekh (1596_CR68) 2021
C Lee (1596_CR11) 2016
HE Park (1596_CR12) 2023
X Tang (1596_CR18) 2023
JH Su (1596_CR152) 2020
F Jiang (1596_CR153) 2023
DY Lee (1596_CR69) 2010
E Lubeck (1596_CR27) 2014
AK Srivastava (1596_CR156) 2016
VM Ravi (1596_CR125) 2022
JH Lee (1596_CR17) 2014
S Shah (1596_CR14) 2016
LD Roberts (1596_CR71) 2012
X Zhang (1596_CR147) 2023
P Zheng (1596_CR101) 2023
Y Liu (1596_CR98) 2022
W-C Hsieh (1596_CR108) 2022
R Moncada (1596_CR120) 2020
KR Kumar (1596_CR41) 2019
B Zhang (1596_CR131) 2023
E Mennillo (1596_CR145) 2024
M Slyper (1596_CR94) 2020
TJ Bechtel (1596_CR122) 2021
J Cao (1596_CR8) 2024
EL Van Dijk (1596_CR31) 2014
M Ghaste (1596_CR72) 2016
R Hosea (1596_CR44) 2024
SN Thomas (1596_CR77) 2022
L Tang (1596_CR102) 2023
J Liao (1596_CR20) 2021
A Mund (1596_CR59) 2022
C Martínez-Ruiz (1596_CR114) 2023
DE Wagner (1596_CR130) 2020
JM Rothberg (1596_CR35) 2008
Y Zhi (1596_CR100) 2024
Z Udaondo (1596_CR42) 2021
M Wang (1596_CR5) 2022
PR Prasetyanti (1596_CR109) 2017
A Baysoy (1596_CR1) 2023
M Mou (1596_CR56) 2022
X Chen (1596_CR62) 2023
J Park (1596_CR135) 2022
L Liu (1596_CR36) 2012
H-E Park (1596_CR9) 2023
HH Tang (1596_CR141) 2018
Y Deng (1596_CR89) 2022
N Zamboni (1596_CR79) 2015
E Lundberg (1596_CR60) 2019
M Vicari (1596_CR159) 2024
EL Van Dijk (1596_CR40) 2018
LM Orre (1596_CR57) 2019
JRM Black (1596_CR113) 2021
X Li (1596_CR150) 2023
SA Baker (1596_CR66) 2023
L Kester (1596_CR128) 2018
T Lu (1596_CR87) 2022
Y Yang (1596_CR32) 2014
M Vicari (1596_CR88) 2023
A Fossati (1596_CR55) 2021
Y Zhang (1596_CR63) 2021
B Muster (1596_CR104) 2017
X Bian (1596_CR85) 2024
M Stoeckius (1596_CR95) 2017
I Winkler (1596_CR148) 2024
RR Stickels (1596_CR49) 2021
WJ Wang (1596_CR2) 2023
M Gerstung (1596_CR50) 2020
H Wang (1596_CR139) 2022
References_xml – year: 2022
  ident: 1596_CR89
  publication-title: Nature
  doi: 10.1038/s41586-022-05094-1
– year: 2023
  ident: 1596_CR114
  publication-title: Nature
  doi: 10.1038/s41586-023-05706-4
– year: 2024
  ident: 1596_CR132
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2024.02.007
– year: 2022
  ident: 1596_CR45
  publication-title: Nature
  doi: 10.1038/s41586-021-04217-4
– year: 2021
  ident: 1596_CR133
  publication-title: STAR Protoc
  doi: 10.1016/j.xpro.2021.100532
– year: 2023
  ident: 1596_CR2
  publication-title: Mil Med Res
  doi: 10.1186/s40779-023-00471-x
– year: 2018
  ident: 1596_CR25
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkx1206
– year: 2021
  ident: 1596_CR49
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-020-0739-1
– year: 2018
  ident: 1596_CR141
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2018.02.003
– year: 2023
  ident: 1596_CR153
  publication-title: Nat Methods
  doi: 10.1038/s41592-023-01884-1
– year: 2024
  ident: 1596_CR6
  publication-title: Mol Cancer
  doi: 10.1186/s12943-024-02040-9
– year: 2016
  ident: 1596_CR14
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.10.001
– year: 2024
  ident: 1596_CR142
  publication-title: J Pharm Anal
  doi: 10.1016/j.jpha.2023.11.017
– year: 2012
  ident: 1596_CR80
  publication-title: Anal Chem
  doi: 10.1021/ac202450g
– year: 2022
  ident: 1596_CR65
  publication-title: Cell
  doi: 10.1016/j.cell.2022.10.014
– year: 2022
  ident: 1596_CR135
  publication-title: Genome Biol
  doi: 10.1186/s13059-022-02824-6
– year: 2020
  ident: 1596_CR50
  publication-title: Nature
  doi: 10.1038/s41586-019-1907-7
– year: 2018
  ident: 1596_CR157
  publication-title: Cell
  doi: 10.1016/j.cell.2018.05.035
– year: 2016
  ident: 1596_CR72
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms17060816
– year: 2020
  ident: 1596_CR127
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-020-01941-y
– year: 2023
  ident: 1596_CR9
  publication-title: Advanced Science
  doi: 10.1002/advs.202206939
– year: 2017
  ident: 1596_CR95
  publication-title: Nat Methods
  doi: 10.1038/nmeth.4380
– year: 2021
  ident: 1596_CR29
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-23807-4
– year: 2022
  ident: 1596_CR90
  publication-title: Science
  doi: 10.1126/science.abg7216
– year: 2024
  ident: 1596_CR100
  publication-title: Adv Sci (Weinh)
  doi: 10.1002/advs.202306515
– year: 2021
  ident: 1596_CR28
  publication-title: Mol Syst Biol
  doi: 10.15252/msb.202010108
– year: 2021
  ident: 1596_CR110
  publication-title: Nat Rev Urol
  doi: 10.1038/s41585-020-00400-w
– year: 2013
  ident: 1596_CR39
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2012.11.025
– year: 2023
  ident: 1596_CR147
  publication-title: Hum Reprod Update
  doi: 10.1093/humupd/dmad017
– year: 2022
  ident: 1596_CR87
  publication-title: Cell
  doi: 10.1016/j.cell.2022.09.035
– year: 2023
  ident: 1596_CR131
  publication-title: Nature
  doi: 10.1038/s41586-023-06806-x
– year: 2014
  ident: 1596_CR31
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2014.07.001
– year: 2011
  ident: 1596_CR38
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-12-245
– year: 2012
  ident: 1596_CR75
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3314
– year: 2014
  ident: 1596_CR17
  publication-title: Science
  doi: 10.1126/science.1250212
– year: 2023
  ident: 1596_CR107
  publication-title: Nature
  doi: 10.1038/s41586-023-05869-0
– year: 2022
  ident: 1596_CR96
  publication-title: Nat Commun
  doi: 10.1038/s41467-022-28445-y
– year: 2024
  ident: 1596_CR145
  publication-title: Nat Commun
  doi: 10.1038/s41467-024-45665-6
– year: 2010
  ident: 1596_CR19
  publication-title: Nat Methods
  doi: 10.1038/nmeth.1448
– year: 2021
  ident: 1596_CR111
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-21615-4
– year: 2022
  ident: 1596_CR139
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2022.02.010
– year: 2021
  ident: 1596_CR146
  publication-title: Protein Cell
  doi: 10.1007/s13238-020-00757-z
– year: 2013
  ident: 1596_CR16
  publication-title: Nat Methods
  doi: 10.1038/nmeth.2563
– year: 2021
  ident: 1596_CR68
  publication-title: Nat Methods
  doi: 10.1038/s41592-021-01197-1
– year: 2023
  ident: 1596_CR136
  publication-title: Med Rev
  doi: 10.1515/mr-2023-0046
– year: 2023
  ident: 1596_CR26
  publication-title: Genom Proteom Bioinform
  doi: 10.1016/j.gpb.2022.10.001
– year: 2012
  ident: 1596_CR36
  publication-title: J Biomed Biotechnol
  doi: 10.1155/2012/251364
– volume: 437
  start-page: 376
  issue: 7057
  year: 2005
  ident: 1596_CR37
  publication-title: Nature
  doi: 10.1038/nature03959
– year: 2012
  ident: 1596_CR76
  publication-title: Mol Biosyst
  doi: 10.1039/c1mb05350g
– year: 2016
  ident: 1596_CR73
  publication-title: Comput Struct Biotechnol J
  doi: 10.1016/j.csbj.2016.02.005
– year: 2017
  ident: 1596_CR83
  publication-title: PLoS Comput Biol
  doi: 10.1371/journal.pcbi.1005839
– year: 2015
  ident: 1596_CR51
  publication-title: Traffic
  doi: 10.1111/tra.12310
– year: 2023
  ident: 1596_CR102
  publication-title: Nat Methods
  doi: 10.1038/s41592-023-02110-8
– year: 2015
  ident: 1596_CR21
  doi: 10.1038/nprot.2014.191
– year: 2015
  ident: 1596_CR79
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2015.04.021
– year: 2022
  ident: 1596_CR5
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2022.04.006
– year: 2023
  ident: 1596_CR66
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/s41580-022-00572-w
– year: 2021
  ident: 1596_CR113
  publication-title: Nat Rev Cancer
  doi: 10.1038/s41568-021-00336-2
– year: 2019
  ident: 1596_CR48
  publication-title: Science
  doi: 10.1126/science.aaw1219
– year: 2008
  ident: 1596_CR35
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt1485
– year: 2011
  ident: 1596_CR30
  publication-title: Respirology
  doi: 10.1111/j.1440-1843.2010.01899.x
– start-page: 173
  volume-title: Alternative Splicing: Methods and Protocols
  year: 2022
  ident: 1596_CR10
  doi: 10.1007/978-1-0716-2521-7_10
– year: 2021
  ident: 1596_CR3
  publication-title: Nature
  doi: 10.1038/s41586-021-03634-9
– year: 2020
  ident: 1596_CR91
  publication-title: Cell
  doi: 10.1016/j.cell.2020.10.026
– year: 2015
  ident: 1596_CR151
  publication-title: Science
  doi: 10.1126/science.aaa6090
– year: 2022
  ident: 1596_CR118
  publication-title: Nat Commun
  doi: 10.1038/s41467-022-34208-6
– year: 2023
  ident: 1596_CR62
  publication-title: Cell Death Differ
  doi: 10.1038/s41418-023-01213-1
– year: 2019
  ident: 1596_CR60
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/s41580-018-0094-y
– year: 2022
  ident: 1596_CR98
  publication-title: Res Sq
  doi: 10.21203/rs.3.rs-1499315/v1
– year: 2023
  ident: 1596_CR138
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2023.01.009
– year: 2022
  ident: 1596_CR116
  publication-title: Cell Genom
  doi: 10.1016/j.xgen.2022.100165
– year: 2023
  ident: 1596_CR88
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-023-01937-y
– year: 2021
  ident: 1596_CR55
  publication-title: Nat Methods
  doi: 10.1038/s41592-021-01107-5
– year: 2021
  ident: 1596_CR20
  publication-title: Trends Biotechnol
  doi: 10.1016/j.tibtech.2020.05.006
– year: 2019
  ident: 1596_CR57
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2018.11.035
– year: 2024
  ident: 1596_CR134
  publication-title: Curr Opin Nephrol Hypertens
  doi: 10.1097/mnh.0000000000000988
– year: 2018
  ident: 1596_CR70
  publication-title: J Inherit Metab Dis
  doi: 10.1007/s10545-017-0130-7
– year: 2018
  ident: 1596_CR22
  doi: 10.1126/science.aat5691
– year: 2022
  ident: 1596_CR67
  publication-title: Metabolites
  doi: 10.3390/metabo12040357
– year: 2020
  ident: 1596_CR124
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-17186-5
– year: 2021
  ident: 1596_CR47
  doi: 10.1126/science.aay3446
– year: 2024
  ident: 1596_CR85
  publication-title: Adv Sci (Weinh)
  doi: 10.1002/advs.202305724
– year: 2024
  ident: 1596_CR149
  publication-title: Cell Discov
  doi: 10.1038/s41421-024-00656-1
– year: 2022
  ident: 1596_CR86
  publication-title: Cell
  doi: 10.1016/j.cell.2022.04.003
– year: 2017
  ident: 1596_CR104
  publication-title: AIMS Genet
  doi: 10.3934/genet.2017.1.47
– year: 2023
  ident: 1596_CR7
  publication-title: Biomolecules
  doi: 10.3390/biom13010156
– year: 2022
  ident: 1596_CR56
  publication-title: J Chem Inf Model
  doi: 10.1021/acs.jcim.2c01161
– year: 2024
  ident: 1596_CR44
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-024-01767-7
– year: 2022
  ident: 1596_CR59
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-022-01302-5
– year: 2021
  ident: 1596_CR119
  publication-title: Lab Invest
  doi: 10.1038/s41374-021-00612-7
– year: 2023
  ident: 1596_CR140
  publication-title: Adv Sci
  doi: 10.1002/advs.202205395
– year: 2010
  ident: 1596_CR69
  publication-title: Biotechniques
  doi: 10.2144/000113451
– year: 2017
  ident: 1596_CR13
  publication-title: Neuron
  doi: 10.1016/j.neuron.2017.05.008
– year: 2019
  ident: 1596_CR123
  publication-title: Cell
  doi: 10.1016/j.cell.2019.06.024
– year: 2022
  ident: 1596_CR126
  publication-title: Immunity
  doi: 10.1016/j.immuni.2022.11.002
– year: 2014
  ident: 1596_CR27
  publication-title: Nat Methods
  doi: 10.1038/nmeth.2892
– year: 2020
  ident: 1596_CR130
  publication-title: Nat Rev Genet
  doi: 10.1038/s41576-020-0223-2
– year: 2022
  ident: 1596_CR154
  publication-title: Immunity
  doi: 10.1016/j.immuni.2022.09.002
– year: 2023
  ident: 1596_CR160
  publication-title: Adv Sci (Weinh)
  doi: 10.1002/advs.202205395
– year: 2020
  ident: 1596_CR120
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-019-0392-8
– year: 2021
  ident: 1596_CR42
  publication-title: Life (Basel)
  doi: 10.3390/life11080862
– year: 2022
  ident: 1596_CR105
  publication-title: Science
  doi: 10.1126/science.abm1741
– year: 2018
  ident: 1596_CR23
  doi: 10.1038/s41576-018-0045-7
– year: 2023
  ident: 1596_CR24
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.3c02029
– year: 2019
  ident: 1596_CR84
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-019-0290-0
– year: 2018
  ident: 1596_CR128
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2018.04.014
– year: 2021
  ident: 1596_CR54
  publication-title: Nat Rev Methods Primers
  doi: 10.1038/s43586-021-00029-y
– year: 2023
  ident: 1596_CR92
  publication-title: MedComm
  doi: 10.1002/mco2.315.6
– year: 2023
  ident: 1596_CR1
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/s41580-023-00615-w
– year: 2010
  ident: 1596_CR74
  publication-title: Adv Protein Chem Struct Biol
  doi: 10.1016/B978-0-12-381264-3.00002-3
– year: 2020
  ident: 1596_CR94
  publication-title: Nat Med
  doi: 10.1038/s41591-020-0844-1
– year: 2024
  ident: 1596_CR15
  publication-title: Nat Commun
  doi: 10.1038/s41467-024-46437-y
– year: 2022
  ident: 1596_CR97
  publication-title: Front Oncol
  doi: 10.3389/fonc.2022.890410
– year: 2016
  ident: 1596_CR11
  publication-title: Methods
  doi: 10.1016/j.ymeth.2015.12.007
– year: 2014
  ident: 1596_CR81
  publication-title: Anal Chem
  doi: 10.1021/ac503092d
– year: 2012
  ident: 1596_CR71
  publication-title: Curr Protoc Mol Biol
  doi: 10.1002/0471142727.mb3002s98
– year: 2019
  ident: 1596_CR41
  publication-title: Semin Thromb Hemost
  doi: 10.1055/s-0039-1688446
– year: 2018
  ident: 1596_CR52
  publication-title: Small GTPases
  doi: 10.1080/21541248.2017.1397833
– year: 2023
  ident: 1596_CR121
  publication-title: Nat Commun
  doi: 10.1038/s41467-023-38360-5
– year: 2022
  ident: 1596_CR106
  publication-title: Nature
  doi: 10.1038/s41586-022-05060-x
– year: 2024
  ident: 1596_CR144
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.18396
– year: 2022
  ident: 1596_CR143
  publication-title: Sci Adv
  doi: 10.1126/sciadv.abm5500
– year: 2022
  ident: 1596_CR77
  publication-title: Nat Rev Methods Primers
  doi: 10.1038/s43586-022-00175-x
– year: 2019
  ident: 1596_CR158
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1912459116
– year: 2020
  ident: 1596_CR152
  publication-title: Cell
  doi: 10.1016/j.cell.2020.07.032
– year: 2022
  ident: 1596_CR108
  publication-title: J Biomed Sci
  doi: 10.1186/s12929-022-00879-y
– year: 2021
  ident: 1596_CR93
  publication-title: Nature
  doi: 10.1038/s41586-020-03126-2
– year: 2024
  ident: 1596_CR103
  publication-title: Nat Biomed Eng
  doi: 10.1038/s41551-024-01205-7
– year: 2018
  ident: 1596_CR40
  publication-title: Trends Genet TIG
  doi: 10.1016/j.tig.2018.05.008
– year: 2019
  ident: 1596_CR61
  publication-title: FEBS J
  doi: 10.1111/febs.14938
– year: 2024
  ident: 1596_CR148
  publication-title: Cell
  doi: 10.1016/j.cell.2024.01.021
– year: 2014
  ident: 1596_CR32
  publication-title: Genom Proteom Bioinform
  doi: 10.1016/j.gpb.2014.09.001
– year: 2017
  ident: 1596_CR112
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1616288
– year: 2024
  ident: 1596_CR8
  publication-title: Theranostics
  doi: 10.7150/thno.95908
– year: 2014
  ident: 1596_CR34
  publication-title: Trends In Genetics : TIG
  doi: 10.1016/j.tig.2014.07.001
– year: 2023
  ident: 1596_CR18
  publication-title: J Genet Genom
  doi: 10.1016/j.jgg.2023.02.004
– year: 2021
  ident: 1596_CR63
  publication-title: Adv Exp Med Biol
  doi: 10.1007/978-981-15-8104-5_1
– year: 2021
  ident: 1596_CR122
  publication-title: Nat Chem Biol
  doi: 10.1038/s41589-021-00790-x
– year: 2023
  ident: 1596_CR12
  publication-title: Adv Sci (Weinh)
  doi: 10.1002/advs.202206939
– year: 2022
  ident: 1596_CR43
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-0716-2521-7_10
– year: 2019
  ident: 1596_CR78
  publication-title: Analyst
  doi: 10.1039/c8an01581c
– year: 2023
  ident: 1596_CR99
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms24054992
– year: 2021
  ident: 1596_CR4
  publication-title: Nat Methods
  doi: 10.1038/s41592-020-01033-y
– year: 2022
  ident: 1596_CR58
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2022.05.022
– year: 2023
  ident: 1596_CR117
  publication-title: J Agric Food Chem
  doi: 10.1021/acs.jafc.3c01377
– year: 2023
  ident: 1596_CR155
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-023-01676-0
– year: 2023
  ident: 1596_CR137
  publication-title: Nat Rev Cancer
  doi: 10.1038/s41568-023-00557-7
– year: 2022
  ident: 1596_CR46
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2022.05.010
– year: 2024
  ident: 1596_CR159
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-023-01937-y
– year: 2018
  ident: 1596_CR53
  publication-title: Handb Exp Pharmacol
  doi: 10.1007/164_2018_103
– year: 2012
  ident: 1596_CR115
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1113205
– year: 2016
  ident: 1596_CR156
  publication-title: Hum Genom
  doi: 10.1186/s40246-016-0063-5
– year: 2017
  ident: 1596_CR109
  publication-title: Mol Cancer
  doi: 10.1186/s12943-017-0600-4
– year: 2023
  ident: 1596_CR101
  publication-title: Cell Rep Med
  doi: 10.1016/j.xcrm.2023.101057
– year: 2022
  ident: 1596_CR125
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2022.05.009
– year: 2021
  ident: 1596_CR129
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2020.10.021
– volume: 35
  start-page: 169
  issue: 3
  year: 2014
  ident: 1596_CR33
  publication-title: Clin Biochem Rev
– year: 2018
  ident: 1596_CR64
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.118.310998
– year: 2023
  ident: 1596_CR150
  publication-title: Nat Neurosci
  doi: 10.1038/s41593-023-01312-9
– year: 2018
  ident: 1596_CR82
  publication-title: High Throughput
  doi: 10.3390/ht7020009
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Snippet The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context among cell...
Abstract The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context...
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StartPage 72
SubjectTerms Accuracy
Animals
Bar codes
Biological analysis
Cancer research
Cancer therapies
Cells
Crosstalk
Developmental biology
Efficiency
Gene expression
Genomes
Genomic analysis
Genomics
Genomics - methods
Heterogeneity
Humans
Hybridization
Lineage tracking
Localization
Medical research
Metabolites
Metabolomics - methods
Methods
Molecular modelling
Multiomics
Neoplasms - genetics
New therapy
Proteomes
Proteomics - methods
Review
Spatial heterogeneity
Spatial multi-omics
Spatial-specific atlas
Technology
Transcriptomes
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Title Spatial multi-omics: deciphering technological landscape of integration of multi-omics and its applications
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Volume 17
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