Snail-overexpressing Cancer Cells Promote M2-Like Polarization of Tumor-Associated Macrophages by Delivering MiR-21-Abundant Exosomes

• Published in: Neoplasia (New York, N.Y.) Vol. 20; no. 8; pp. 775 - 788
• Main Authors: Hsieh, Chia-Hsin, Tai, Shyh-Kuan, Yang, Muh-Hwa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2018; Elsevier Limited; Neoplasia Press; Elsevier
• Subjects: Angiogenesis; Cancer; CD14 antigen; Colonization; Exosomes; Head & neck cancer; Invasiveness; Macrophages; Mesenchyme; Metastases; Microenvironments; Monocytes; Original article; Phenotypes; Polarization; Snail protein; TAM; FBS; HNSCC; TEX; DLS; ChIP; EMT; TEM; PBMC; TME

Epithelial-mesenchymal transition (EMT) is a major event during cancer progression and metastasis; however, the definitive role of EMT in remodeling tumor microenvironments (TMEs) is unclear. Tumor-associated macrophages (TAMs) are a major type of host immune cells in TMEs, and they perform a wide r...