Expression of the blood-group-related glycosyltransferase B4galnt2 influences the intestinal microbiota in mice

• Published in: The ISME Journal Vol. 6; no. 7; pp. 1345 - 1355
• Main Authors: Staubach, Fabian, Künzel, Sven, Baines, Andrea C, Yee, Andrew, McGee, Beth M, Bäckhed, Fredrik, Baines, John F, Johnsen, Jill M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2012; Oxford University Press; Nature Publishing Group
• Subjects: 1984; 631/181/457; 631/326/2565/855; 692/698/2741/2135; Abundance; Animals; Annan medicin och hälsovetenskap; antigen; ao a; B4galnt2; bacteria; Bacteria - classification; Bacteria - genetics; Biomedical and Life Sciences; Blood; blood group; disease; Ecology; Evolutionary Biology; Female; Gastroenteritis; Gastrointestinal tract; Gene expression; Genotypes; glycosylation; Glycosyltransferase; gut; Helicobacter; helicobacter-pylori; Homeostasis; Intestinal microflora; Intestine; Intestines - microbiology; Life Sciences; Male; Metagenome; Mice; Mice, Inbred C57BL; Microbial Ecology; Microbial Genetics and Genomics; Microbiology; microbiota; mouse; Mucosa; N-Acetylgalactosaminyltransferases - genetics; N-Acetylgalactosaminyltransferases - metabolism; Natural selection; Original; original-article; Other Medical and Health Sciences; p265; Polysaccharides; rna; RNA, Bacterial - genetics; RNA, Ribosomal, 16S - genetics; rRNA 16S; scandinavian journal of statistics; Selection, Genetic; sequence; Siblings; Specific Pathogen-Free Organisms; Taxa; v11; von-willebrand-factor; microbiota; blood group; mouse; glycosylation; intestine

Glycans on mucosal surfaces have an important role in host–microbe interactions. The locus encoding the blood-group-related glycosyltransferase β- 1,4-N-acetylgalactosaminyltransferase 2 ( B4galnt2 ) is subject to strong selective forces in natural house-mouse populations that contain a common allel...