Pyroptosis, ferroptosis, and autophagy in spinal cord injury: regulatory mechanisms and therapeutic targets

• Published in: Neural regeneration research Vol. 20; no. 10; pp. 2787 - 2806
• Main Authors: Zheng, Qingcong, Wang, Du, Lin, Rongjie, Xu, Weihong
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow 01.10.2025; Medknow Publications & Media Pvt. Ltd; Department of Spinal Surgery,the First Affiliated Hospital of Fujian Medical University,Fuzhou,Fujian Province,China%Arthritis Clinical and Research Center,Peking University People's Hospital,Beijing,China%Department of Orthopedic Surgery,Fujian Medical University Union Hospital,Fuzhou,Fujian Province,China; Wolters Kluwer Medknow Publications
• Edition: 2
• Subjects: Autophagy; Cell death; Ferroptosis; inflammation; pathological mechanisms; pyroptosis; regulated cell death; regulatory pathways; Review; Spinal cord injuries; spinal cord injury; therapeutic targets; regulated cell death; spinal cord injury; pyroptosis; autophagy; ferroptosis; pathological mechanisms; cell death; inflammation; therapeutic targets; regulatory pathways

Regulated cell death is a form of cell death that is actively controlled by biomolecules. Several studies have shown that regulated cell death plays a key role after spinal cord injury. Pyroptosis and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate...