Adult Tissue Extracellular Matrix Determines Tissue Specification of Human iPSC‐Derived Embryonic Stage Mesodermal Precursor Cells

• Published in: Advanced science Vol. 7; no. 5; pp. 1901198 - n/a
• Main Authors: Ullah, Imran, Busch, Jonas Felix, Rabien, Anja, Ergün, Bettina, Stamm, Christof, Knosalla, Christoph, Hippenstiel, Stefan, Reinke, Petra, Kurtz, Andreas
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.03.2020; John Wiley and Sons Inc; Wiley
• Subjects: cell differentiation; Extracellular matrix; Heart; Heparan sulfate; Morphogenesis; pluripotent stem cells; regenerative medicine; Stem cells; tissue engineering; Variables; cell differentiation; tissue engineering; pluripotent stem cells; regenerative medicine; extracellular matrix

The selection of pluripotent stem cell (PSC)‐derived cells for tissue modeling and cell therapy will be influenced by their response to the tissue environment, including the extracellular matrix (ECM). Whether and how instructive memory is imprinted in adult ECM and able to impact on the tissue spec...