Icariin inhibits hypoxia/reoxygenation‐induced ferroptosis of cardiomyocytes via regulation of the Nrf2/HO‐1 signaling pathway - Liu, Xiu‐Juan; Lv, Yan‐Fei; Cui, Wen‐Zhu; Li, Yan; Liu, Yang; Xue, Yi‐Tao; Dong, Feng (FEBS open bio, 2021)
Keywords: Apoptosis; Apoptosis - drug effects; Bioengineering; Blood flow; Cardiomyocytes; Cell death; Cell Hypoxia - drug effects; Cell Hypoxia - physiology; Cell Line; Cell Survival - drug effects; Dehydrogenases; Endoplasmic reticulum; Ferroptosis; Flavonoids - metabolism; Flavonoids - pharmacology; Heart attacks; Hypoxia; Hypoxia - drug therapy; Hypoxia - metabolism; hypoxia/reoxygenation; icariin; Iron; Ischemia; L-Lactate dehydrogenase; lactate dehydrogenase; Lactic acid; Membranes; Myocardial infarction; Myocardial Reperfusion Injury - metabolism; Myocardium; Myocytes, Cardiac - drug effects; NF-E2-Related Factor 2 - drug effects; NF-E2-Related Factor 2 - metabolism; Nrf2/HO‐1 pathway; Oxidative stress; Oxidative Stress - drug effects; Plaques; protective effect; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Signal transduction; Signal Transduction - drug effects; Software; viability; United States--US; China; Germany; cardiomyocytes; icariin; Nrf2/HO-1 pathway; ferroptosis; oxidative stress; hypoxia/reoxygenation