Cytotoxic activity of methanolic fractions of different Marrubium spp. against melanoma cells is independent of antioxidant activity and total phenolic content

• Published in: FEBS open bio Vol. 10; no. 1; pp. 86 - 95
• Main Authors: Kozyra, Malgorzata, Korga, Agnieszka, Ostrowska, Marta, Humeniuk, Ewelina, Adamczuk, Grzegorz, Gieroba, Renata, Makuch‐Kocka, Anna, Dudka, Jaroslaw
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.01.2020; John Wiley and Sons Inc; Wiley
• Subjects: alkaline hydrolysis; antineoplastic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; antioxidant activity; Antioxidants; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Antitumor activity; Ballota; Bioactive compounds; Biological activity; Biphenyl Compounds - antagonists & inhibitors; Cancer; Cancer therapies; cancer therapy; Cell cycle; Cell Cycle - drug effects; cell lines; Cell Proliferation - drug effects; Cell Survival - drug effects; Cell viability; Cells, Cultured; Comparative analysis; Cytotoxicity; Drug development; Drug Screening Assays, Antitumor; esterification; Fibroblasts; Flavonoids; free phenolic acid; Gene expression; Herbal medicine; Humans; in vitro cytotoxicity; Marrubium; Marrubium - chemistry; Marrubium vulgare; Melanoma; Melanoma - drug therapy; Melanoma - metabolism; Melanoma - pathology; Methanol - chemistry; Molecular Structure; neoplasm cells; Phenolic acids; Phenols - analysis; Picrates - antagonists & inhibitors; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Reagents; skin (animal); Stainless steel; Sterols; United Kingdom > UK; Poland; United States > US; in vitro cytotoxicity; melanoma; Marrubium; antioxidant activity; free phenolic acid

The Marrubium genus (horehound) has proved to be an abundant source of biologically active compounds, but there is little knowledge about its potential anticancer activity. Moreover, some Marrubium species have not been the subject of study in this regard. In this study, we performed comparative ana...