Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner

• Published in: Advanced science Vol. 8; no. 18; pp. e2004303 - n/a
• Main Authors: Guo, Jianping, Cheng, Ji, Zheng, Nana, Zhang, Xiaomei, Dai, Xiaoming, Zhang, Linli, Hu, Changjiang, Wu, Xueji, Jiang, Qiwei, Wu, Depei, Okada, Hitoshi, Pandolfi, Pier Paolo, Wei, Wenyi
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.09.2021; John Wiley and Sons Inc; Wiley
• Subjects: 3-Phosphoinositide-Dependent Protein Kinases - metabolism; AKT; Animals; Autophagy; breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Cancer; Carcinogenesis - genetics; Carcinogenesis - metabolism; Cell growth; copper; Copper - metabolism; Copper Transporter 1 - genetics; Copper Transporter 1 - metabolism; CTR1; Female; Fibroblasts; Growth factors; Homeostasis; Humans; Insulin; Kinases; Metabolism; Mice; Mutation; Nedd4l; PDK1; Phosphorylation; Physiology; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Roles; Signal Transduction - genetics; Tumorigenesis; breast cancer; copper; AKT; Nedd4l; CTR1; PDK1

Copper plays pivotal roles in metabolic homoeostasis, but its potential role in human tumorigenesis is not well defined. Here, it is revealed that copper activates the phosphoinositide 3‐kinase (PI3K)‐protein kinase B (PKB, also termed AKT) oncogenic signaling pathway to facilitate tumorigenesis. Me...