Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner - Guo, Jianping; Cheng, Ji; Zheng, Nana; Zhang, Xiaomei; Dai, Xiaoming; Zhang, Linli; Hu, Changjiang; Wu, Xueji; Jiang, Qiwei; Wu, Depei; Okada, Hitoshi; Pandolfi, Pier Paolo; et al. (Advanced science, 2021)
Keywords: 3-Phosphoinositide-Dependent Protein Kinases - metabolism; AKT; Animals; Autophagy; breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Cancer; Carcinogenesis - genetics; Carcinogenesis - metabolism; Cell growth; copper; Copper - metabolism; Copper Transporter 1 - genetics; Copper Transporter 1 - metabolism; CTR1; Female; Fibroblasts; Growth factors; Homeostasis; Humans; Insulin; Kinases; Metabolism; Mice; Mutation; Nedd4l; PDK1; Phosphorylation; Physiology; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Roles; Signal Transduction - genetics; Tumorigenesis; breast cancer; copper; AKT; Nedd4l; CTR1; PDK1