Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone, against noise-induced hearing loss

• Published in: Journal of neuroscience research Vol. 93; no. 5; pp. 788 - 795
• Main Authors: Yamashita, Daisuke, Sun, Guang-wei, Cui, Yong, Mita, Shiro, Otsuki, Naoki, Kanzaki, Sho, Nibu, Ken-ichi, Ogawa, Kaoru, Matsunaga, Tatsuo
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.05.2015; Wiley Subscription Services, Inc
• Subjects: Acoustic Stimulation - adverse effects; Acoustics; Age Factors; Animals; Animals, Newborn; cell death; cochlea; Cochlea - drug effects; Cochlea - growth & development; Cochlea - metabolism; cutamesine; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem - drug effects; Follow-Up Studies; Gene Expression Regulation - drug effects; Hearing Loss, Noise-Induced - diagnosis; Hearing Loss, Noise-Induced - drug therapy; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; noise-induced hearing loss; Organ of Corti - metabolism; Organ of Corti - pathology; Piperazines - pharmacology; Piperazines - therapeutic use; Receptors, sigma - agonists; Sodium-Potassium-Exchanging ATPase - metabolism; spiral limbus; cochlea; noise-induced hearing loss; cutamesine; cell death; spiral limbus
• ISSN: 0360-4012; 1097-4547; 1097-4547
• DOI: 10.1002/jnr.23543

The sigma‐1 receptor, which is expressed throughout the brain, provides physiological benefits that include higher brain function. The sigma‐1 receptor functions as a chaperone in the endoplasmic reticulum and may control cell death and regeneration within the central nervous system. Cutamesine (1‐(...