谷胱甘肽硫转移酶M1基因多态和吸烟与贲门癌易感性关系研究

R735.2; 目的探讨谷胱甘肽硫转移酶M1(GSTM1)基因多态和吸烟与贲门癌易感性关联.方法 GSTM1基因多态性用多重PCR技术检测.结果 GSTM1空白基因型在贲门癌组( 62.5%)、低分化贲门癌组( 69.2%)与对照组( 46.5%)之间的频率差异均有显著性(P< 0.05).GSTM1空白基因型在重度吸烟的贲门癌组( 75.0%)与对照组( 47.1%)之间的频率差异有显著性(P< 0.05).结论 GSTM1空白基因型与贲门癌遗传易感性有关,肿瘤多呈低分化腺癌;重度吸烟可显著提高GSTM1空白基因型个体患贲门癌的危险性....

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Published in肿瘤防治研究 Vol. 31; no. 7; pp. 441 - 443
Main Authors 张友才, 邓长生, 朱尤庆
Format Journal Article
LanguageChinese
Published 430071,武汉大学中南医院消化内科 2004
Subjects
吸烟
贲门癌
谷胱甘肽S-转移酶
Online AccessGet full text
ISSN1000-8578
DOI10.3971/j.issn.1000-8578.2004.07.025

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Abstract R735.2; 目的探讨谷胱甘肽硫转移酶M1(GSTM1)基因多态和吸烟与贲门癌易感性关联.方法 GSTM1基因多态性用多重PCR技术检测.结果 GSTM1空白基因型在贲门癌组( 62.5%)、低分化贲门癌组( 69.2%)与对照组( 46.5%)之间的频率差异均有显著性(P< 0.05).GSTM1空白基因型在重度吸烟的贲门癌组( 75.0%)与对照组( 47.1%)之间的频率差异有显著性(P< 0.05).结论 GSTM1空白基因型与贲门癌遗传易感性有关,肿瘤多呈低分化腺癌;重度吸烟可显著提高GSTM1空白基因型个体患贲门癌的危险性.
AbstractList R735.2; 目的探讨谷胱甘肽硫转移酶M1(GSTM1)基因多态和吸烟与贲门癌易感性关联.方法 GSTM1基因多态性用多重PCR技术检测.结果 GSTM1空白基因型在贲门癌组( 62.5%)、低分化贲门癌组( 69.2%)与对照组( 46.5%)之间的频率差异均有显著性(P< 0.05).GSTM1空白基因型在重度吸烟的贲门癌组( 75.0%)与对照组( 47.1%)之间的频率差异有显著性(P< 0.05).结论 GSTM1空白基因型与贲门癌遗传易感性有关,肿瘤多呈低分化腺癌;重度吸烟可显著提高GSTM1空白基因型个体患贲门癌的危险性.
Author 张友才
朱尤庆
邓长生
AuthorAffiliation 430071,武汉大学中南医院消化内科
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贲门癌
谷胱甘肽S-转移酶
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Snippet R735.2; 目的探讨谷胱甘肽硫转移酶M1(GSTM1)基因多态和吸烟与贲门癌易感性关联.方法 GSTM1基因多态性用多重PCR技术检测.结果 GSTM1空白基因型在贲门癌组( 62.5%)、低分化贲门癌组( 69.2%)与对照组( 46.5%)之间的频率差异均有显著性(P<...
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StartPage 441
Title 谷胱甘肽硫转移酶M1基因多态和吸烟与贲门癌易感性关系研究
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