Immunological characterization of a VIR protein family member (VIR-14) in Plasmodium vivax-infected subjects from different epidemiological regions in Africa and South America

• Published in: PLoS neglected tropical diseases Vol. 17; no. 4; p. e0011229
• Main Authors: Fantin, Raianna F., Coelho, Camila H., Berhe, Anne D., Magalhães, Luisa M. D., Pereira, Dhélio B., Salinas, Nichole D., Tolia, Niraj H., Amaratunga, Chanaki, Suon, Seila, Sagara, Issaka, Narum, David L., Fujiwara, Ricardo T., Abejon, Claudia, Campos-Neto, Antonio, Duffy, Patrick E., Bueno, Lilian L.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2023; Public Library of Science (PLoS)
• Subjects: Amino acids; Antibodies; Antibodies, Protozoan; Antibody response; Antigens; Antigens, Protozoan; Biology; Biology and Life Sciences; Brazil - epidemiology; CD27 antigen; CD4 antigen; CD8 antigen; Cells; Cloning; Drug resistance; E coli; Enzymes; Epidemiology; Ethics; Family; Flow cytometry; Geographical distribution; Health aspects; Health care; High frequency; Host-parasite interactions; Human diseases; Humans; Immune system; Immunity; Immunoglobulin G; Immunology; Infections; Informed consent; Levels; Liver; Lymphocytes; Lymphocytes B; Lymphocytes T; Malaria; Malaria, Falciparum - epidemiology; Malaria, Vivax - parasitology; Mali - epidemiology; Medicine and Health Sciences; Parasites; People and places; Plasmodium falciparum; Plasmodium vivax; Plasmodium vivax - genetics; Prevention; Proteins; Protozoan Proteins - genetics; Receptors; Research and Analysis Methods; Tropical diseases; Vaccines; Vector-borne diseases; Virulence; Brazil; Mali; South America; Africa; Amazon Basin; Cambodia; United States > US

Plasmodium vivax is a major challenge for malaria control due to its wide geographic distribution, high frequency of submicroscopic infections, and ability to induce relapses due to the latent forms present in the liver (hypnozoites). Deepening our knowledge of parasite biology and its molecular com...