BUB1 drives the occurrence and development of bladder cancer by mediating the STAT3 signaling pathway

• Published in: Journal of experimental & clinical cancer research Vol. 40; no. 1; p. 378
• Main Authors: Jiang, Ning, Liao, Yihao, Wang, Miaomiao, Wang, Youzhi, Wang, Keke, Guo, Jianing, Wu, Peikang, Zhong, Boqiang, Guo, Tao, Wu, Changli
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.12.2021; BioMed Central; BMC
• Subjects: Animals; Bladder cancer; Breast cancer; BUB1; Cell Proliferation; Chemotherapy; Chromosomes; Development and progression; Genetic transcription; Glycerol; Humans; Kinases; Lymphoma; Male; Mice; Patients; Phosphorylation; Proliferation; Protein Serine-Threonine Kinases - metabolism; Proteins; Signal Transduction; STAT3; STAT3 Transcription Factor - metabolism; Thermal cycling; Transfection; Transgenic animals; Tumorigenesis; Urinary Bladder Neoplasms - genetics; United States > US; Phosphorylation; Proliferation; BUB1; Bladder cancer; STAT3

The incidence of bladder urothelial carcinoma (UC), a common malignancy of the urinary tract, is approximately three times higher in men than in women. High expression of the mitotic kinase BUB1 is associated with the occurrence and development of several cancers, although the relationship between B...