Renal Recovery for Patients with ANCA-Associated Vasculitis and Low eGFR in the ADVOCATE Trial of Avacopan

• Published in: Kidney international reports Vol. 8; no. 4; pp. 860 - 870
• Main Authors: Bruchfeld, Annette, Bekker, Pirow, Luxton, G., Ranganathan, D., Lhotta, K., Hellemans, R., Hougardy, J., Sprangers, B., Wissing, K., Pagnoux, C., Barbour, S., Brachemi, S., Becvar, R., Gregersen, J., Lyngsoe, C., Rigothier, C., Karras, A., Klein, A., Maurier, F., Moranne, O., Schaier, M., Grundmann, F., Haller, H., Haubitz, M., Henes, J., Hohenstein, B., Iking-Konert, C., Kubacki, T., Kotter, I., Halbritter, J., Mehling, H., Venhoff, N., Brunetta, E., Dagna, L., Emmi, G., Manenti, L., Atsumi, T., Kaneko, Y., Katagiri, A., Kirino, Y., Kitagawa, K., Komatsuda, A., Kono, H., Kurasawa, T., Matsumura, R., Morinobu, A., Nanki, T., Oshima, H., Sada, K., Tamura, N., Tsukamoto, T., Rutgers, A., Walker, R., Collins, M., de Zoysa, J., Kalstad, S., Clarkson, M., Ciggaran, S., Oliveras, X. Fulladosa, Rusinol, H. Marco, Segarra, A., Westman, K., Burnier, M., Daikeler, T., Hauser, T., Seeger, H., Vogt, B., Amin, T., Brogan, P., Dasgupta, B., Doulton, T., Flossmann, O., Griffin, S., Klocke, R., Lanyon, P., McLaren, J., Makanjuola, D., Selvan, S., O'Riordan, E., Pusey, C., Robson, J., Robson, M., Sznajd, J., Taylor, J., Belilos, E., Chen Lin, Y. Chang, Dragoi, S., Dua, A., Geetha, D., Kivitz, A., Koening, C., Langford, C., Mohamed, A., Monach, P., Parks, D., Sam, R., Striebich, C., Swarup, A., Thakar, S., Wasko, M. Chester
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2023; Elsevier
• Subjects: ANCA-associated vasculitis; avacopan; Clinical Research; complement; complement 5a receptor; low eGFR; Medicin och hälsovetenskap; renal recovery; avacopan; complement; complement 5a receptor; renal recovery; ANCA-associated vasculitis; low eGFR

In the 330-patient ADVOCATE trial of avacopan for the treatment of antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, in which 81% of patients had renal involvement, estimated glomerular filtration rate (eGFR) increased on average 7.3 ml/min per 1.73 m2 in the avacopan group and 4...