LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer

• Published in: Journal of experimental & clinical cancer research Vol. 41; no. 1; pp. 315 - 20
• Main Authors: Cave, Donatella Delle, Buonaiuto, Silvia, Sainz, Bruno, Fantuz, Marco, Mangini, Maria, Carrer, Alessandro, Di Domenico, Annalisa, Iavazzo, Tea Teresa, Andolfi, Gennaro, Cortina, Carme, Sevillano, Marta, Heeschen, Christopher, Colonna, Vincenza, Corona, Marco, Cucciardi, Antonio, Di Guida, Martina, Batlle, Eduard, De Luca, Annachiara, Lonardo, Enza
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.10.2022; BioMed Central; BMC
• Subjects: Activin Receptors; Cancer therapies; Carcinoma, Pancreatic Ductal - pathology; Cell Line, Tumor; Cell Movement - genetics; CRISPR; Ethylenediaminetetraacetic acid; Flow cytometry; Growth factors; Health aspects; Humans; Immunohistochemistry; Laminin; Laminin - genetics; Laminin - metabolism; Laminin γ2 (LAMC2); Lung cancer; Metastasis; Neoplastic Stem Cells - metabolism; Pancreatic cancer; Pancreatic ductal adenocarcinoma (PDAC); Pancreatic Neoplasms; Pancreatic Neoplasms - pathology; Proteins; Receptor, Transforming Growth Factor-beta Type I; RNA; RNA sequencing; RNA, Messenger; RNA, Small Interfering; Software; Spheres; Statistical significance; Stem cells; Student's t-test; TGF-β signaling; Transforming Growth Factor beta; Transforming growth factors; Tumor-initiating cells (TICs); Tumors; Vactosertib; Germany; Laminin γ2 (LAMC2); Tumor-initiating cells (TICs); Pancreatic ductal adenocarcinoma (PDAC); Vactosertib; TGF-β signaling

Tumor-initiating cells (TIC), also known as cancer stem cells, are considered a specific subpopulation of cells necessary for cancer initiation and metastasis; however, the mechanisms by which they acquire metastatic traits are not well understood. LAMC2 transcriptional levels were evaluated using p...