LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer - Cave, Donatella Delle; Buonaiuto, Silvia; Sainz, Bruno; Fantuz, Marco; Mangini, Maria; Carrer, Alessandro; Di Domenico, Annalisa; Iavazzo, Tea Teresa; Andolfi, Gennaro; Cortina, Carme; Sevillano, Marta; Heeschen, Christopher; et al. (Journal of experimental & clinical cancer research, 2022)
Keywords: Activin Receptors; Cancer therapies; Carcinoma, Pancreatic Ductal - pathology; Cell Line, Tumor; Cell Movement - genetics; CRISPR; Ethylenediaminetetraacetic acid; Flow cytometry; Growth factors; Health aspects; Humans; Immunohistochemistry; Laminin; Laminin - genetics; Laminin - metabolism; Laminin γ2 (LAMC2); Lung cancer; Metastasis; Neoplastic Stem Cells - metabolism; Pancreatic cancer; Pancreatic ductal adenocarcinoma (PDAC); Pancreatic Neoplasms; Pancreatic Neoplasms - pathology; Proteins; Receptor, Transforming Growth Factor-beta Type I; RNA; RNA sequencing; RNA, Messenger; RNA, Small Interfering; Software; Spheres; Statistical significance; Stem cells; Student's t-test; TGF-β signaling; Transforming Growth Factor beta; Transforming growth factors; Tumor-initiating cells (TICs); Tumors; Vactosertib; Germany; Laminin γ2 (LAMC2); Tumor-initiating cells (TICs); Pancreatic ductal adenocarcinoma (PDAC); Vactosertib; TGF-β signaling